Recombinant PARK7 Monoclonal Antibody (AN301285L)
For research use only.
| Verified Samples | Verified Samples in IHC: Human lung cancer |
| Dilution | IHC 1:4000-1:20000 |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human PARK7 protein |
| Abbre | PARK7 |
| Synonyms | GATD, PARK, DJ-1, DJ1, GATD2, HEL-S-67p, PARK7, PARK7 |
| Swissprot | |
| Cellular Localization | Cell membrane, Lipid-anchor, Cytoplasm, Nucleus, Membrane raft, Mitochondrion, Endoplasmic reticulum, Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745). Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation. |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Neuroscience, Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Metabolism |
| Clone No. | 4D1 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. |
Other Clones
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Unconjugated
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