Recombinant PD1 Monoclonal Antibody (AN301420L)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human spleen, Human tonsil Verified Samples in IF: Molt4 |
| Dilution | IHC 1:200-1:1000, IF 1:50 |
| Isotype | IgG, κ |
| Host | Rabbit |
| Reactivity | Human, |
| Applications | IHC, IF |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Synthetic peptide derived from the human PD1 protein |
| Abbre | PD1 |
| Synonyms | SLEB, hSLE, Programmed Death, programmed cell death, Programmed cell death protein, Systemic lupus erythematosus susceptibility, hPD, PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, programmed cell death 1, PD 1, CD279 antigen, hPD 1, hPD l, PDCD 1, Programmed cell death 1 protein, Programmed Death-1, Protein PD 1, Protein PD-1, Systemic lupus erythematosus susceptibility 2, Programmed cell death protein 1, CD279, CD279 antigen, hPD 1, hPD l, hPD-1, hSLE1, PD 1, PD-1, PD1, PDCD 1, PDCD1, PDCD1, Programmed cell death 1, Programmed cell death 1 protein, Programmed cell death protein 1, Protein PD 1, Protein PD-1, SLEB2, Systemic lupus erythematosus susceptibility 2 |
| Swissprot | |
| Cellular Localization | Membrane |
| Concentration | 1 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A purified |
| Research Areas | Cell Biology, Immunology, Cancer |
| Clone No. | A115 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | The programmed cell death 1 protein (PD1) is an inhibitory receptor expressed on antigen activated T-cells that plays a critical role in the induction and maintenance of immune tolerance to self-antigens. Upon binding to its ligands CD274/PDCD1L1 (PD-L1) and CD273/PDCD1LG2 (PD-L2), PD1 is phosphorylated within its immunoreceptor tyrosine-based switch motif (ITSM), which facilitates the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2. PTPN11/SHP-2 then dephosphorylates key T-cell receptor (TCR) proximal signaling molecules, including ZAP70, PRKCQ/PKC theta and CD247/CD3 zeta, leading to the direct inhibition of T-cell activation. The PD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and evade destruction by the immune system, thereby facilitating tumor survival. |
Other Clones
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Other Formats
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Unconjugated
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