Recombinant PI3 Kinase p85 alpha Monoclonal Antibody (AN301629L)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human bladder cancer, Human pancreatic cancer Verified Samples in IF: HepG2, NIH3T3 |
| Dilution | IHC 1:50-1:100, IF 1:50 |
| Isotype | IgG, κ |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC, IF |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant human PI3 Kinase p85 alpha fragment |
| Abbre | PI3 Kinase p85 alpha |
| Synonyms | GRB, IMD, AGM, PIK3R, AGM7, GRB1, IMD36, p85, p85-ALPHA, PI3 Kinase p85 alpha, PIK3R1, p85 alpha, P85A, Phosphatidylinositol 3 kinase, Phosphatidylinositol 3 kinase associated p 85 alpha, Phosphatidylinositol 3 kinase regulatory 1, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphoinositide 3 kinase, PI3 kinase p85 subunit alpha, PI3K, PI3K regulatory subunit alpha, PI3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, polypeptide 1 (p85 alpha), PtdIns 3 kinase p85 alpha, PtdIns-3-kinase regulatory subunit alpha, PtdIns-3-kinase regulatory subunit p85-alpha, regulatory subunit, regulatory subunit 1 (alpha) |
| Swissprot | |
| Cellular Localization | Cytosol, Membrane |
| Concentration | 1 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A purified |
| Research Areas | Signal Transduction, Cancer, Immunology, Metabolism |
| Clone No. | A332 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement. |
Other Clones
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Other Formats
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Unconjugated
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