Recombinant Rat EGFR/ErbB1 Protein (His Tag) (PKSR030363)
For research use only.
| Synonyms | EGFR |
| Species | Rat |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Ser646 |
| Accession | E7CXR8 |
| Calculated Molecular Weight | 70.7 kDa |
| Observed Molecular Weight | 93-110 kDa |
| Tag | C-His |
| Bio-activity | Measured by its ability to bind recombinant human EGF-Fc and mouse EGF-Fc in functional ELISA. |
| Form | Lyophilized powder |
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently. |
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