Recombinant Renin/REN/Angiotensinogenase Monoclonal Antibody (AN300357P)
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For research use only.
| Verified Samples | Verified Samples in IHC:paraffin-embedded human kidney |
| Dilution | IHC-P 1:200-1:2000 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC-P, FCM, ICC/IF |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human Renin protein |
| Abbre | REN |
| Synonyms | HNFJ, REN, HNFJ2, renin, Angiotensin forming enzyme, Angiotensin forming enzyme precursor, Angiotensin-forming enzyme, Angiotensinogenase precursor, FLJ10761, Ren1, RENI, Renin precursor renal, Angiotensinogenase |
| Swissprot | |
| Calculated MW | 45 kDa |
| Cellular Localization | Secreted |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Affinity Purification |
| Research Areas | Cardiovascular, Signal Transduction, Metabolism |
| Clone | B279 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008] |
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