Recombinant S100A12 Monoclonal Antibody (AN300131P)

Name: Recombinant S100A12 Monoclonal Antibody
Brand: Elabscience
SKU: AN300131P
Price: 380.0 USD
Availability: InStock

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Recombinant S100A12 Monoclonal Antibody - 1

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	100μL	$ 380.00	- +

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Verified Samples	Verified Samples in IF: HeLa
Dilution	WB: 1:1000；IHC-P: 1:1000-1:5000；ICC/IF: 1:100；FC: 1:200-1:500；IP: 1:20-1:50
Isotype	IgG
Host	Rabbit
Reactivity	Human
Applications	WB, IHC-P, ICC/IF, FC, IP
Clonality	Recombinant;Monoclonal
Immunogen	Recombinant Human S100A12 protein
Abbre	S100A12
Synonyms	CAAF, S100A, MRP, S100A12, CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6, Calgranulin C, CAGC, Calgranulin C, CGRP, ENRAGE, MRP6, S100A12, Calcitermin, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, Calgranulin-related protein, EN RAGE, EN-RAGE, Extracellular newly identified RAGE-binding protein, migration inhibitory factor-related protein 6, Neutrophil S100 protein, Protein S100 A12, Protein S100-A12, S100 calcium binding protein A12, S100 calcium-binding protein A12, S100 calcium-binding protein A12 (calgranulin C), S10AC
Swissprot	P80511
Calculated MW	11 kDa
Observed MW	11 kDa Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include: 1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein. 2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes. 3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1. 4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids). 5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers. If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane.
Cellular Localization	Secreted, Cytoplasm, Cytoskeleton, Cell membrane.
Concentration	1 mg/mL
Buffer	0.2 μm filtered solution in PBS
Purification Method	Protein A
Research Areas	Immunology, Signal Transduction
Clone	A1245
Conjugation	Unconjugated
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping	Ice bag
background	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]