Recombinant S100A8 Monoclonal Antibody (AN300035P)
For research use only.
| Verified Samples | Verified Samples in IHC: Human spleen |
| Dilution | IHC-P 1:100-1:500, |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC-P |
| Clonality | Rabbit Monoclonal |
| Immunogen | Recombinant Human S100A8 protein |
| Abbre | S100A8 |
| Synonyms | Protein S100-A, S100a, Kcnip, KCHIP, MRP, S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, Calgranulin A, Calgranulin-A, Cystic fibrosis antigen, Leukocyte L1 complex light chain, MRP-8, Protein S100-A8, CALP, KCNIP4, KCHIP4, AI323541, B8Ag, BEE11, Calprotectin, Calprotectin L1L subunit, Chemotactic cytokine CP-10, included, Migration inhibitory factor-related protein 8, Myeloid-related protein 8, Neutrophil cytosolic 7 kDa protein, Pro-inflammatory S100 cytokine, S100 calcium binding protein A8, S100 calcium binding protein A8 (calgranulin A), S100 calcium-binding protein A8, S100A8/S100A9 complex, S10A8, Urinary stone protein band A |
| Swissprot | |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Neuroscience, Cancer, Immunology, Signal Transduction, Cell Biology, Epigenetics and Nuclear Signaling |
| Clone No. | 8D7 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | S100A8/S100A9 HeterodimerS100A8 (also MRP8 and calgranulin A) is a 10 kDa member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (termed calprotectin) with S100A9. It functions both intracellularly and extracellularly, where it binds to RAGE and CD36. Human S100A8 is 93 amino acids (aa) in length. It contains two EF-hand motifs (aa 12 - 47 and 46 - 81) and one high-affinity Ca2+-binding site (aa 59 - 70). There may be one splice form that shows a 15 aa substitution for the C-terminal 14 amino acids. Although mouse S100A8 is cleaved by MMP-2 after Asn21, it is unclear if human S100A8 is susceptible. Full-length human S100A8 is 57% and 74% aa identical to mouse and canine S100A8, respectively. |
Other Clones
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Unconjugated
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