Recombinant SATB1 Monoclonal Antibody (AN301653L)

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	100μL	$ 380.00	- +
	50μL	$ 249.00	- +

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Verified Samples	Verified Samples in IHC: Human ovarian cancer, Human tonsil, Mouse spleen, Rat spleen Verified Samples in IF: Jurkat
Dilution	IHC 1:200-1:1000, IF 1:50
Isotype	IgG, κ
Host	Rabbit
Reactivity	Human, Rat, Mouse
Applications	IHC, IF
Clonality	Monoclonal;Recombinant
Immunogen	Recombinant human SATB1 fragment
Abbre	SATB1
Synonyms	SATB, SATB1
Swissprot	Q01826
Cellular Localization	Nucleus
Concentration	1 mg/mL
Buffer	PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Purification Method	Protein A purified
Research Areas	Epigenetics and Nuclear Signaling
Clone No.	A356
Conjugation	Unconjugated
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping	Ice bag
background	Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.

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Unconjugated