Recombinant SH-PTP1 Monoclonal Antibody (AN301193L)
For research use only.
| Verified Samples | Verified Samples in IHC: Human tonsil |
| Dilution | IHC 1:500-1:1000 |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human SH-PTP1 protein |
| Abbre | SH-PTP1 |
| Synonyms | CTCN, PTPN, Protein-Tyrosine Phosphatase SHP, Tyrosine-Protein Phosphatase Non-Receptor Type, SH-PTP, SHP, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, CTCN6, PTPN6, Hematopoietic Cell Protein-Tyrosine Phosphatase, Protein-Tyrosine Phosphatase 1C, Protein-Tyrosine Phosphatase SHP-1, Tyrosine-Protein Phosphatase Non-Receptor Type 6, PTP1C, 70Z-SHP, EC 3.1.3.48, Hematopoietic cell phosphatase, Hematopoietic cell protein tyrosine phosphatase, Protein tyrosine phosphatase 1C, Protein tyrosine phosphatase non receptor type 6, Protein tyrosine phosphatase SHP1, protein-tyrosine phosphatase SHP 1, PTN6, PTP 1C, SH PTP 1, SH PTP1, SHP 1, SHP 1L, SHP1L, Src homology region 2 domain-containing phosphatase-1, tyrosine protein phosphatase non receptor type 6, SH-PTP1 |
| Swissprot | |
| Cellular Localization | Cytoplasm, Nucleus, In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Cell Biology, Signal Transduction, Cancer, Developmental Biology |
| Clone No. | 5D6 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. |
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Unconjugated
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