RNF111 Polyclonal Antibody (E-AB-18773)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human gastric cancer, Human thyroid cancer |
| Dilution | IHC 1:50-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human RNF111 |
| Abbre | RNF111 |
| Synonyms | ARK, Arkadia, DKFZp313E0731, DKFZp686H1966, DKFZp761D081, E3 ubiquitin protein ligase Arkadia, E3 ubiquitin-protein ligase Arkadia, FLJ38008, RING finger protein 111, RN111, RNF 111, RNF111 |
| Swissprot | |
| Cellular Localization | Nucleus. Cytoplasm. Upon TGF-beta treatment, translocates from nucleus to cytosol. |
| Concentration | 0.84 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cell Biology, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase.This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription.As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |
Other Clones
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Other Formats
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Unconjugated
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