SLC22A17 Polyclonal Antibody (E-AB-12870)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human brain |
| Dilution | IHC 1:25-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human SLC22A17 |
| Abbre | SLC22A17 |
| Synonyms | 24p3 receptor, 24p3R, BOCT, BOIT, Brain type organic cation transporter, Brain-type organic cation transporter, Lipocalin-2 receptor, NGAL receptor, Neutrophil gelatinase associated lipocalin receptor, Neutrophil gelatinase-associated lipocalin receptor, Ngal, hBOIT |
| Swissprot | |
| Cellular Localization | Cell membrane. Vacuole membrane. Upon LCN2-binding, it is internalized. |
| Concentration | 0.3 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. |
Other Clones
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Other Formats
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Unconjugated
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