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For research use only.

Verified Samples Verified Samples in IHC: Human colon cancer, Human lung cancer
Dilution IHC 1:25-1:100
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse
Applications IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human SMG8
Abbre SMG8
Synonyms ABC 2,  ABC2,  Amplified in breast cancer gene 2 protein,  Chromosome 17 open reading,  FLJ10587,  Protein smg 8 homolog,  SMG8,  SMG8 protein,  chromosome 17 open reading frame 71,  protein SMG8
Swissprot
Cellular Localization Cytosol
Concentration 0.3 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.
Other Clones

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Unconjugated

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