SOCS1 Polyclonal Antibody (E-AB-12648)
For research use only.
| Verified Samples |
Verified Samples in WB: 231 Verified Samples in IHC: Human ovarian cancer, Human gastric cancer |
| Dilution | WB 1:1000-1:5000, IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human SOCS1 |
| Abbre | SOCS1 |
| Synonyms | CISH 1, CISH1, Cytokine inducible SH2 protein 1, JAB, JAK binding protein, JAK-binding protein, Janus kinase binding protein, SOCS 1, SOCS-1, SOCS1, SSI 1, SSI-1, SSI1, STAT induced STAT inhibitor 1, STAT-induced STAT inhibitor 1, Socs1, Suppressor of cytokine signaling |
| Swissprot | |
| Calculated MW | 24 kDa |
| Cellular Localization | Cytosol, Nucleus, nucleoplasm, Other locations: cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic vesicle. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. |
Other Clones
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Other Formats
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Unconjugated
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