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For research use only.

Verified Samples Verified Samples in IHC: Human cervical cancer, Human thyroid cancer
Dilution IHC 1:40-1:200
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications IHC
Clonality Polyclonal
Immunogen Fusion protein of human STAU2
Abbre STAU2
Synonyms RNA-binding protein) homolog 2,  39K2,  39K3,  DKFZp781K0371,  Double stranded RNA binding protein Staufen homolog 2,  Double-stranded RNA-binding protein Staufen homolog 2,  MGC119606,  STAU 2,  STAU2,  Staufen (Drosophila,  Staufen double-stranded RNA binding protei,  stau2
Swissprot
Cellular Localization Cytoplasm. Nucleus. Nucleus>nucleolus. Endoplasmic reticulum. Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted.
Concentration 0.78 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Epigenetics and Nuclear Signaling,  Neuroscience
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles.These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures.Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively.The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.Several transcript variants encoding different isoforms have been found for this gene.
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Unconjugated

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