TAB1 Polyclonal Antibody (E-AB-15186)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human liver cancer, Human thyroid cancer |
| Dilution | IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human TAB1 |
| Abbre | TAB1 |
| Synonyms | 2310012M03Rik, 3'-Tab1, MAP3K7IP 1, MAP3K7IP1, MGC57664, Mitogen activated protein kinase kinase kinase 7 interacting protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAB 1, TAB1, TAK1 binding protein 1, TAK1-binding protein 1 |
| Swissprot | |
| Cellular Localization | Cytosol, Endosome membrane, Nucleus, nuclear speck, Other locations: protein complex. |
| Concentration | 0.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cardiovascular, Immunology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. |
Other Clones
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Other Formats
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Unconjugated
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