TCF7 Polyclonal Antibody (E-AB-53275)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human lung cancer, Human prostate cancer |
| Dilution | IHC 1:40-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human TCF7 |
| Abbre | TCF7 |
| Synonyms | FLJ36364, MGC47735, OTTHUMP00000159391, T cell factor 1, T cell specific transcription factor 1, T-cell factor 1, T-cell-specific transcription factor 1, TCF-1, TCF-7, TCF1, TCF7, TCF7 transcription factor 7, Tcf7, Tran, Transcription factor 7 (T cell specific HMG box) |
| Swissprot | |
| Cellular Localization | Nucleus. |
| Concentration | 0.78 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling, Immunology, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators.This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development.The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway.Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation.Alternative splicing results in multiple transcript variants.Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. |
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