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For research use only.

Verified Samples Verified Samples in IHC: Mouse liver, Rat brain
Dilution IHC 1:100-200
Isotype IgG
Host Mouse
Reactivity Mouse,  Rat
Applications IHC-p
Clonality Monoclonal
Immunogen Synthetic Peptide of TGFβ1
Abbre TGFβ1 Mouse (5D2)
Synonyms CED,  Cartilage-inducing factor,  DPD1,  Differentiation inhibiting factor,  LAP,  Latency-associated peptide,  Prepro transforming growth factor beta 1,  TGF beta,  TGF beta 1,  TGF beta 1 protein,  TGF-beta 1 protein,  TGF-beta-1,  TGF-beta-5,  TGF-beta1,  TGFB,  TGFB1,  Tgfb-1,  tgfb1
Swissprot
Cellular Localization Secreted>extracellular space>extracellular matrix.
Tissue Specificity Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.
Concentration 1 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
Purification Method Protein A purification
Research Areas Cancer,  Cardiovascular,  Metabolism,  Signal Transduction,  Stem Cells
Clone No. 5D2
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.
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Unconjugated

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