TNK2 Polyclonal Antibody (E-AB-12226)
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For research use only.
| Verified Samples |
Verified Samples in WB: 231 Verified Samples in IHC: Human breast cancer, Human liver cancer |
| Dilution | WB 1:1000-1:5000, IHC 1:50-1:200 |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human TNK2 |
| Abbre | TNK2 |
| Synonyms | Acetate kinase 1, Acetokinase 1, ACK, ACK 1, ACK-1, ACK1, Activated Cdc42 associated kinase 1, Activated CDC42 kinase 1, Activated p21cdc42Hs kinase, FLJ44758, FLJ45547, p21cdc42Hs, TNK 2, TNK2, Tyrosine kinase non receptor 2, Tyrosine kinase non receptor protein 2 |
| Swissprot | |
| Calculated MW | 119 kDa |
| Cellular Localization | Cell membrane. Nucleus. Endosome. Cell junction>adherens junction. Cytoplasmic vesicle membrane. The Tyr-284 phosphorylated form is expressed both in the membrane and nucleus. Co-localizes with EGFR on the endosomes. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. |
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