TPX2 Polyclonal Antibody (E-AB-17129)
For research use only.
| Verified Samples |
Verified Samples in WB: K562, A431 |
| Dilution | WB 1:500-2000 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human TPX2 |
| Abbre | TPX2 |
| Synonyms | C20ORF1, C20orf2, Chromosome 20 Open Reading Frame 1, Differentially expressed i, Differentially expressed in cancerous and non-cancerous lung cells 2, Differentially expressed in cancerous and noncancerous lung cells 2, Differentially expressed in lung cells 2 |
| Swissprot | |
| Calculated MW | 86 kDa |
| Cellular Localization | Nucleus. Cytoplasm>cytoskeleton>spindle. Cytoplasm>cytoskeleton>spindle pole. During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. |
| Concentration | 0.9 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell biology, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | TPX2 (targeting protein for Xklp2) is a microtubule-associated protein involved in targeting the motor protein Xklp2 to microtubules.Ran-GTP activates TPX2 for the chromatin-induced microbutule assembly during M phase.Aurora-A kinase associates with TPX2 at the spindle apparatus and may regulate TPX2 via phosphorylation during the spindle assembly.TPX2 appears to play a structural role in spindle formation.TPX2 activates Eg2 in a microtubule-dependent manner by stimulating the phosphorylation and kinase activity of Eg2. |
Other Clones
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Other Formats
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Unconjugated
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