TPX2 Polyclonal Antibody (E-AB-17130)
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For research use only.
| Verified Samples |
Verified Samples in WB: A431, 293T, Hela, K562 Verified Samples in IHC: Human esophagus cancer |
| Dilution | WB 1:500-2000, IHC 1:30-150 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human TPX2 |
| Abbre | TPX2 |
| Synonyms | C20ORF1, C20orf2, Chromosome 20 Open Reading Frame 1, Differentially expressed i, Differentially expressed in cancerous and non-cancerous lung cells 2, Differentially expressed in cancerous and noncancerous lung cells 2, Differentially expressed in lung cells 2 |
| Swissprot | |
| Calculated MW | 86 kDa |
| Cellular Localization | Nucleus. Cytoplasm>cytoskeleton>spindle. Cytoplasm>cytoskeleton>spindle pole. During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell biology, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. |
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