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For research use only.

Verified Samples Verified Samples in IHC: Human thyroid cancer, Human breast cancer
Dilution IHC 1:30-1:150
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human TRIM25
Abbre TRIM25
Synonyms E3 ubiquitin/ISG15 ligase TRIM25,  EFP,  Estrogen responsive finger protein,  Estrogen-responsive finger protein,  RING finger protein 147,  RNF 147,  RNF147,  TRI25,  TRIM 25,  Trim25,  Tripartite m,  Tripartite motif containing 25,  Tripartite motif containing protein 25
Swissprot
Cellular Localization Cytoplasm. Colocalized with DDX58 at cytoplasmic perinuclear bodies.
Concentration 0.7 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Cell Biology,  Epigenetics and Nuclear Signaling,  Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.
Other Clones

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Unconjugated

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