Uncoated Human VEGFR3/Flt4 (Vascular Endothelial Cell Growth Factor Receptor 3) ELISA Kit (E-UNEL-H0349)
Product Summary
The new series of Elabscience® Uncoated ELISA kits contain the basic components required for the ELISA experiments. For customers who have rich experience and can establish their own ELISA system, uncoated kit is an ideal choice to save costs.
| Detection Range | 0.16-10 ng/mL |
| Sample Volume | 100 μL |
| Total Assay Time | 24 h |
| Reactivity | Human |
| Specificity | This kit recognizes Human VEGFR3/Flt4 in samples.No significant cross-reactivity or interference between Human VEGFR3/Flt4 and analogues was observed |
| Recovery | 80%-120% |
| Sample Type | Serum, plasma |
| Detection Method | Colorimetric method, ELISA, Sandwich |
| Assay Type | Sandwich-ELISA |
| Size | 96T*5 / 96T*15 |
| Storage | -20℃ |
| Expiration Date | 12 months |
Background
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD; and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation; survival and migration of endothelial cells; and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC; and to a lesser degree VEGFA; thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction; because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2; MAPK3/ERK1 signaling pathway; of MAPK8 and the JUN signaling pathway; and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1; the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185'; and of AKT1 at 'Ser-473'
| Gene ID | 2324 |
| Uniport ID | P35916 |
| Research Area | Cancer , Cardiovascular , Epigenetics And Nuclear Signaling , Signal Transduction |
| Cat.No. | Product Name | Clone No. |
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