UPF1 Polyclonal Antibody (E-AB-13000)
For research use only.
| Verified Samples |
Verified Samples in WB: Raji Verified Samples in IHC: Human liver cancer, Human thyroid cancer |
| Dilution | WB 1:200-1:1000, IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human UPF1 |
| Synonyms | ATP dependent helicase RENT1, ATP-dependent helicase RENT1, Delta helicase, FLJ43809, FLJ46894, HUPF 1, KIAA0221, NORF 1, NORF1, Nonsense mRNA reducing factor 1, RENT 1, RENT1, Regulator of nonsense transcripts 1, Smg 2, Smg 2 homolog nonsens, hUpf1, pNORF 1, pNORF1 |
| Swissprot | |
| Calculated MW | 124 kDa |
| Cellular Localization | Cytoplasm. Cytoplasm>P-body. Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm. |
| Concentration | 0.1 mg/mL |
| Buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a protein that is part of a post-splicing multiprotein complex involved in botHuman, MouseRNA nuclear export and mRNA surveillance.mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.This protein is located only in the cytoplasm.When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.Use of multiple polyadenylation sites has been noted for this gene. |
Other Clones
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Other Formats
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Unconjugated
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