UPF1 Polyclonal Antibody (E-AB-13000)
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For research use only.
| Verified Samples |
Verified Samples in WB: Raji Verified Samples in IHC: Human liver cancer, Human thyroid cancer |
| Dilution | WB 1:200-1:1000, IHC 1:50-1:200 |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human UPF1 |
| Abbre | UPF1 |
| Synonyms | ATP dependent helicase RENT1, ATP-dependent helicase RENT1, Delta helicase, FLJ43809, FLJ46894, HUPF 1, hUpf1, KIAA0221, Nonsense mRNA reducing factor 1, NORF 1, NORF1, pNORF 1, pNORF1, Regulator of nonsense transcripts 1, RENT 1, RENT1, Smg 2, Smg 2 homolog nonsens, Smg 2 homolog nonsense mediated mRNA decay factor, UP Frameshift 1, Up frameshift mutation 1 homolog, Up frameshift mutation 1 homolog (S. cerevisiae), Up frameshift suppressor 1 homolog, Up-frameshift suppressor 1 homolog, UPF 1, UPF 1 regulator of nonsense transcripts homolog, upf1, UPF1 regulator of nonsense transcripts homolog, UPF1 RNA helicase and ATPase, Yeast Upf1p homolog抗体 |
| Swissprot | |
| Calculated MW | 124 kDa |
| Cellular Localization | Cytoplasm. Cytoplasm>P-body. Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm. |
| Concentration | 0.1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a protein that is part of a post-splicing multiprotein complex involved in botHuman, MouseRNA nuclear export and mRNA surveillance.mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.This protein is located only in the cytoplasm.When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.Use of multiple polyadenylation sites has been noted for this gene. |
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