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200μL $ 399.00
120μL $ 240.00
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For research use only.

Verified Samples Verified Samples in WB: Raji
Verified Samples in IHC: Human liver cancer, Human thyroid cancer
Dilution WB 1:200-1:1000,  IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse
Applications WB,  IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human UPF1
Synonyms ATP dependent helicase RENT1,  ATP-dependent helicase RENT1,  Delta helicase,  FLJ43809,  FLJ46894,  HUPF 1,  KIAA0221,  NORF 1,  NORF1,  Nonsense mRNA reducing factor 1,  RENT 1,  RENT1,  Regulator of nonsense transcripts 1,  Smg 2,  Smg 2 homolog nonsens,  hUpf1,  pNORF 1,  pNORF1
Swissprot
Calculated MW 124 kDa
Cellular Localization Cytoplasm. Cytoplasm>P-body. Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm.
Concentration 0.1 mg/mL
Buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method Affinity purification
Research Areas Cancer,  Epigenetics and Nuclear Signaling
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background This gene encodes a protein that is part of a post-splicing multiprotein complex involved in botHuman, MouseRNA nuclear export and mRNA surveillance.mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.This protein is located only in the cytoplasm.When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.Use of multiple polyadenylation sites has been noted for this gene.
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Unconjugated

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