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For research use only.

Verified Samples Verified Samples in IHC: Human cervical cancer, Human tonsil
Dilution IHC 1:30-1:150
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications IHC
Clonality Polyclonal
Immunogen Fusion protein of human ZNF354A
Abbre ZNF354A
Synonyms and developmentally regulated protein 1,   ischemia,  EZNF,  HKL1,  HLK1,  Homo sapiens zinc finger protein 354A,  KID 1,  KID1,  Kidney,  Renal transcription factor Kid 1 ,  TCF-17,  TCF17,  Transcription factor 17,  Z354A,  ZNF354,  Zinc finger protein 354A,  Zinc finger protein eZNF
Swissprot
Cellular Localization Nucleus.
Concentration 0.5 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Epigenetics and Nuclear Signaling,  Neuroscience
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Krüppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.
Other Clones

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Unconjugated

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