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For research use only.

Verified Samples Verified Samples in IHC: Human breast cancer, Human esophagus cancer
Dilution IHC 1:40-1:250
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC
Clonality Polyclonal
Immunogen Fusion protein of human ZNF486
Abbre ZNF486
Synonyms KRAB box only protein 2 ,  KRBO2 ,  Zinc finger protein 486
Swissprot
Cellular Localization Nucleus
Concentration 0.9 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Epigenetics and Nuclear Signaling
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF486 (Zinc finger protein 486), also known as KRAB domain only protein 2, is a 216 amino acid nuclear protein that contains one KRAB domain and two C2H2-type zinc fingers. The gene encoding ZNF486 maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. May be involved in transcriptional regulation.
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Unconjugated

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