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What is the difference between PGD2 and PGE2?

Source: Elabscience®Published: Mar 08,2024

These two belong to different types of prostaglandins. Prostaglandin E2 (PGE2) is the most abundant prostaglandin and is produced by the action of prostaglandin E synthetase on prostaglandin H2(PGH2). Prostaglandin D2(PGD2) is another prostaglandin produced by hematopoietic and lipoprotein prostaglandin D synthase (hPGDS and lPGDS) acting on prostaglandin H2(PGH2). In addition, the two have different receptors and different areas of study. PGE2: Mainly studies gastrointestinal smooth muscle PGD2: Studies allergic diseases such as asthma