ELISA Research
Does the Mouse IL1B elisa test for precusor or mature IL1B?
Source: Elabscience®Published: Mar 08,2024
The interleukin (IL)-1 family of cytokines is associated with immune response and inflammation. It consists of the following 11 different molecular forms: Intercellular IL-1α (IL-1F1), extracellular IL-1β (IL-1F2), IL-1 receptor antagonist (IL-1Ra, IL-1F3), And IL-18 (IL-1F4), IL-33 (IL-1F11), IL-36α (IL-1F6), IL-36β (IL-1F8), IL-36γ (IL-1F9), IL-36Ra (IL-1F5), IL-37 (IL-1F7), and IL-38 (L-1F10). One of the most important pro-inflammatory cytokines is IL-1β. It is primarily an inactive 31 kDa precursor produced by monocytes and macrophages, interleukin-1β (proIL-1β), which under the action of cysteine protease IL-1 convertase (ICE) produces a mature and biologically active 17.5kDa protein IL-1β.The E-EL-M0037 kit detects mature IL-1β.