Alternate Names	CKRL3, CMKBR6, GPR29, STRL22,GPRCY4
Swissprot	P51684
References	1. Zaballos A, et al. 1996. Biochem. Bioph. Res. Co. 227:846. 2. Yang D, et al. 1999. Science 286:525. 3. MacDonald KG, et al. 2007. Am. J. Pathol. 170:1229. 4. Homey B, et al. 2000. J. Immunol. 164:6621. 5. Hirota K, et al. 2007. J. Exp. Med. 204:2803. 6. Singh SP, et al. 2008. J. Immunol. 180:214.

Product Details

Form	Liquid
Clone No.	G034E3(See Other Available Formats)
Host	Mouse
Isotype	Mouse IgG2b, κ
Isotype Control	APC Mouse IgG2b, κ Isotype Control[MPC-11] [Product E-AB-F09812E]
Reactivity	Human
Application	FCM (See the Application Description)
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping	Biological ice pack at 4℃
Stability & Storage	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Conjugation	APC
	APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).

How to select the appropriate detection channel through the spectrogram?

Background

CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

Protocols & Troubleshootings

Related Protocols	Staining Cell Surface Targets for Flow Cytometry
Troubleshooting	Troubleshooting for Flow Cytometry

Alternative Formats

Product Name	Sizes	Price
FITC Anti-Human CD196/CCR6 Antibody[G034E3]	20Tests, 100Tests, 100Tests×2	Check More
PE Anti-Human CD196/CCR6 Antibody[G034E3]	20Tests, 100Tests, 100Tests×2	Check More
PE/Cyanine7 Anti-Human CD196/CCR6 Antibody[G034E3]	20Tests, 100Tests, 100Tests×2	Check More

Citations

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