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Cat.No.:E-AB-F1233UE
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Alternate Names | Endoglin,END,Eng |
Swissprot | Q63961 |
References |
1. Gougos A and M. Letarte 1988. J. Immunol. 141:1925.
2. Cheifetz S, et al. 1992. J. Bio. Chem. 267:19027. 3. Barbara NP, et al. 1999. J. Bio. Chem. 274:584. 4. Lastres P, et al. 1992. Eur. J. Immunol. 22:393. 5. Duff S, et al. 2003. FASEB J. 17:984. 6. Warrington K, et al. 2005. Anticancer Res. 25:185. |
Form | Liquid |
Clone No. | MJ7/18(See Other Available Formats) |
Host | Rat |
Isotype | Rat IgG2a, κ |
Isotype Control | APC Rat IgG2a, κ Isotype Control[2A3] [Product E-AB-F09833E] |
Reactivity | Mouse |
Application | FCM (See the Application Description) |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Recommended Use | Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume]. |
Shipping | Biological ice pack at 4℃ |
Stability & Storage | Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Conjugation | APC |
APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter). | |
How to select the appropriate detection channel through the spectrogram?
CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases. |
Related Protocols | Staining Cell Surface Targets for Flow Cytometry |
Troubleshooting |
Product Name | Sizes | Price |
FITC Anti-Mouse CD105 Antibody[MJ7/18] | 50Tests, 100Tests, 100Tests×2 | Check More |
PE Anti-Mouse CD105 Antibody[MJ7/18] | 50Tests, 100Tests, 100Tests×2 | Check More |
APC Anti-Mouse CD105 Antibody[MJ7/18] | 50Tests, 100Tests, 100Tests×2 | Check More |
PE Anti-Mouse CD105 Antibody[MJ7/18] | 25μg, 100μg | Check More |