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APC Anti-Mouse CD206/MMR Antibody[C068C2]

  • Cat.No.:E-AB-F1135E

  • Applications: FCM,ICFCM
  • Isotype: Rat IgG2a, κ
  • Host: Rat

To Purchase E-AB-F1135E

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Antigen Details

Alternate Names MMR,MR,MRC1,macrophage mannose receptor,mannose receptor
Swissprot Q61830
References
1. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
2. Apostolopoulos V, et al. 2001. Curr. Mol. Med. 1:469.
3. Burgdorf S, et al. 2006. J. Immunol. 176:6770.
4. McKenzie EJ, et al. 2007. J. Immunol. 178:4975.

Product Details

Form Liquid
Clone No. C068C2(See Other Available Formats)
Host Rat
Isotype Rat IgG2a, κ
Isotype Control APC Rat IgG2a, κ Isotype Control[2A3] [Product E-AB-F09832E]
Reactivity Mouse
Application FCM,ICFCM (See the Application Description)
Storage Buffer Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping Biological ice pack at 4℃
Stability & Storage Keep as concentrated solution.
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
Conjugation APC
APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).


How to select the appropriate detection channel through the spectrogram?

Background

CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

Protocols & Troubleshootings

Related Protocols Staining Intracellular Antigens for Flow Cytometry
Troubleshooting

Troubleshooting for Flow Cytometry

Citations

  1. Materials Science & Engineering C-Materials for Biological Applications (2020) IF: 5.88
    κ/β-Carrageenan oligosaccharides promoting polarization of LPS-activated macrophage and their potential in diabetes wound healing

    DOI: 10.1016/j.msec.2020.111830

    PMID: 33579508

    Sample: Raw264.7 Cells
  2. BMC Complementary and Alternative Medicine (2020) IF: 2.833
    Haimufang decoction, a Chinese medicine formula for lung cancer, arrests cell cycle, stimulates apoptosis in NCI-H1975 cells, and induces M1 polarization in RAW 264.7 macrophage cells

    DOI: 10.1186/s12906-020-03031-1

    PMID: 32758223

    Sample: Cell Sample
  3. CARBOHYDRATE POLYMERS (2021) IF: 9.381
    Chemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii

    DOI: 10.1016/j.carbpol.2021.118214

    PMID: 34127216

    Sample: Cell Sample
  4. ACS Applied Materials & Interfaces (2022) IF: 10.383
    Acceleration of Oral Wound Healing under Diabetes Mellitus Conditions Using Bioadhesive Hydrogel

    DOI: 10.1021/acsami.2c17424

    Sample: Thp-1 Cell
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