|Alternate Names||MMR,MR,MRC1,macrophage mannose receptor,mannose receptor|
1. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
2. Apostolopoulos V, et al. 2001. Curr. Mol. Med. 1:469.
3. Burgdorf S, et al. 2006. J. Immunol. 176:6770.
4. McKenzie EJ, et al. 2007. J. Immunol. 178:4975.
|Clone No.||C068C2(See Other Available Formats)|
|Isotype||Rat IgG2a, κ|
|Isotype Control||PE Rat IgG2a, κ Isotype Control[2A3] [Product E-AB-F09833D]|
|Application||FCM,ICFCM (See the Application Description)|
|Storage Buffer||Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.|
|Recommended Use||Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].|
|Shipping||Biological ice pack at 4℃|
|Stability & Storage||Keep as concentrated solution.
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
|PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).|
|CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.|
|Related Protocols||Staining Intracellular Antigens for Flow Cytometry|
|FITC Anti-Mouse CD206 Antibody[C068C2]||50Tests, 100Tests, 100Tests×2||Check More|
|PE Anti-Mouse CD206 Antibody[C068C2]||50Tests, 100Tests, 100Tests×2||Check More|
|APC Anti-Mouse CD206 Antibody[C068C2]||50Tests, 100Tests, 100Tests×2||Check More|
|PE/Cyanine7 Anti-Mouse CD206 Antibody[C068C2]||50Tests, 100Tests, 100Tests×2||Check More|
|FITC Anti-Mouse CD206 Antibody[C068C2]||25μg, 100μg||Check More|
|APC Anti-Mouse CD206 Antibody[C068C2]||25μg, 100μg||Check More|
|PE/Cyanine7 Anti-Mouse CD206 Antibody[C068C2]||25μg, 100μg||Check More|
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|Sample: RAW264.7 cell|
|Sample: Kupffer cells|
|Sample: RAW264.7 cell|
|Sample: S180 xenograft|
|Sample: RAW 264.7 cell|