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PE Anti-Mouse CD206/MMR Antibody[C068C2]

  • Cat.No.:E-AB-F1135D

  • Applications: FCM,ICFCM
  • Isotype: Rat IgG2a, κ
  • Host: Rat

To Purchase E-AB-F1135D

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Price: $90
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Antigen Details

Alternate Names MMR,MR,MRC1,macrophage mannose receptor,mannose receptor
Swissprot Q61830
References
1. Wileman TE, et al. 1986. P. Natl. Acad. Sci. USA 83:2501.
2. Apostolopoulos V, et al. 2001. Curr. Mol. Med. 1:469.
3. Burgdorf S, et al. 2006. J. Immunol. 176:6770.
4. McKenzie EJ, et al. 2007. J. Immunol. 178:4975.

Product Details

Form Liquid
Clone No. C068C2(See Other Available Formats)
Host Rat
Isotype Rat IgG2a, κ
Isotype Control PE Rat IgG2a, κ Isotype Control[2A3] [Product E-AB-F09832D]
Reactivity Mouse
Application FCM,ICFCM (See the Application Description)
Storage Buffer Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping Biological ice pack at 4℃
Stability & Storage Keep as concentrated solution.
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
Conjugation PE
PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).


How to select the appropriate detection channel through the spectrogram?

Background

CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

Protocols & Troubleshootings

Related Protocols Staining Intracellular Antigens for Flow Cytometry
Troubleshooting

Troubleshooting for Flow Cytometry

Citations

  1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022) IF: 6.208
    Hepatocyte-Derived Prostaglandin E2-Modulated Macrophage M1-Type Polarization via mTOR-NPC1 Axis-Regulated Cholesterol Transport from Lysosomes to the Endoplasmic Reticulum in Hepatitis B Virus x Protein-Related Nonalcoholic Steatohepatitis

    DOI: 10.3390/ijms231911660

    PMID: 36232960

    Sample: Kupffer Cells
  2. CERAMICS INTERNATIONAL (2022) IF: 5.532
    Influence of Cu doping on the biocompatibility of zirconia-toughened alumina ceramics for artificial joints

    DOI: 10.1016/j.ceramint.2022.09.291

    Sample: Raw264.7 Cell
  3. Cancers (2021) IF: 6.639
    Macrophages Impair TLR9 Agonist Antitumor Activity through Interacting with the Anti-PD-1 Antibody Fc Domain

    DOI: 10.3390/cancers13164081

    PMID: 34439233

    Sample: Raw264.7 Cell
  4. LIFE SCIENCES (2022) IF: 6.78
    Optimization design of sialic acid derivatives enhances the performance of liposomes for modulating immunosuppressive tumor microenvironments

    DOI: 10.1016/j.lfs.2022.121081

    PMID: 36273630

    Sample: S180 Xenograft
  5. Biomaterials Science (2021) IF: 6.843
    Supramolecular copolymer modified statin-loaded discoidal rHDLs for atherosclerotic anti-inflammatory therapy by cholesterol efflux and M2 macrophage polarization

    DOI: 10.1039/D1BM00610J

    PMID: 34346410

    Sample: Raw 264.7 Cell
  6. Frontiers in Immunology (2022) IF: 7.561
    Paeonol Interferes With Quorum-Sensing in Pseudomonas aeruginosa and Modulates Inflammatory Responses In Vitro and In Vivo.

    DOI: 10.3389/fimmu.2022.896874

    Sample: Raw264.7 Macrophage Cell
  7. Journal of Materials Chemistry B (2022) IF: 7.571
    Fabricating biodegradable calcium phosphate/calcium sulfate cement reinforced with cellulose: in vitro and in vivo studies

    DOI: 10.1039/D2TB02191A

  8. CHEMICAL ENGINEERING JOURNAL (2022) IF: 13.273
    Engineered stem cell biomimetic liposomes carrying levamisole for macrophage immunity reconstruction in leukemia therapy

    DOI: 10.1016/j.cej.2022.137582

    Sample: J774A.1 Cell
  9. Advanced Science (2023) IF: 17.521
    Nanomedicines Reprogram Synovial Macrophages by Scavenging Nitric Oxide and Silencing CA9 in Progressive Osteoarthritis

    DOI: 10.1002/advs.202207490

    PMID: 36748885

    Sample: Raw264.7 Cell
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