PE/Cyanine7 Anti-Human CD196/CCR6 Antibody[ G034E3] E-AB-F1158H

Uniprot : P51684
  • Host: Mouse
  • Applications: FCM
  • Isotype: Mouse IgG2b, κ

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Antigen Details

Alternate Names CKRL3, CMKBR6, GPR29, STRL22,GPRCY4
Swissprot P51684
References
1. Zaballos A, et al. 1996. Biochem. Bioph. Res. Co. 227:846.
2. Yang D, et al. 1999. Science 286:525.
3. MacDonald KG, et al. 2007. Am. J. Pathol. 170:1229.
4. Homey B, et al. 2000. J. Immunol. 164:6621.
5. Hirota K, et al. 2007. J. Exp. Med. 204:2803.
6. Singh SP, et al. 2008. J. Immunol. 180:214.

Product Details

Form Liquid
Clone No. G034E3(See Other Available Formats)
Host Mouse
Isotype Mouse IgG2b, κ
Isotype Control PE/Cyanine7 Mouse IgG2b, κ Isotype Control[MPC-11] [Product E-AB-F09812H]
Reactivity Human
Application FCM (See the Application Description)
Storage Buffer PBS with 0.05% Proclin300, 1% BSA
Recommended Use Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 2 μL or 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping Biological ice pack at 4℃
Stability & Storage Keep as concentrated solution.
Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
Conjugation PE/Cyanine7

Background

CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

Protocols & Troubleshootings

Related Protocols Staining Cell Surface Targets for Flow Cytometry
Troubleshooting

Troubleshooting for Flow Cytometry

Alternative Formats

Cat.No. Product Name Sizes
E-AB-F1158C FITC Anti-Human CD196/CCR6 Antibody[ G034E3] E-AB-F1158C 20 Tests, 50 Tests, 100 Tests, 200 Tests
E-AB-F1158D PE Anti-Human CD196/CCR6 Antibody[ G034E3] E-AB-F1158D 20 Tests, 50 Tests, 100 Tests, 200 Tests
E-AB-F1158E APC Anti-Human CD196/CCR6 Antibody[G034E3] E-AB-F1158E 20 Tests, 50 Tests, 100 Tests, 200 Tests
E-AB-F1158H PE/Cyanine7 Anti-Human CD196/CCR6 Antibody[ G034E3] E-AB-F1158H 20 Tests, 50 Tests, 100 Tests, 200 Tests

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