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Current Position:Home>>Antibodies>>Flow Cytometry Antibodies>> Purified Anti-Human CD274/PD-L1 Antibody[29E.2A3]

Purified Anti-Human CD274/PD-L1 Antibody[29E.2A3]

Uniprot : Q9NZQ7

  • Cat.No.:E-AB-F1133A

  • Applications: FCM
  • Isotype: Mouse IgG2b, κ
  • Host: Mouse

To Purchase E-AB-F1133A

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  • 25μg
  • 100μg
Price: $43.2
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Antigen Details

Alternate Names B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Swissprot Q9NZQ7
References
1. Sharpe A, et al. 2007. Nat. Immunol. 8:239.

Product Details

Form Liquid
Clone No. 29E.2A3(See Other Available Formats)
Host Mouse
Isotype Mouse IgG2b, κ
Isotype Control Purified Mouse IgG2b, κ Isotype Control[MPC-11] [Product E-AB-F09813A]
Reactivity Human
Application FCM (See the Application Description)
Storage Buffer Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Recommended Use Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Shipping Biological ice pack at 4℃
Stability & Storage Keep as concentrated solution.
Store at 2~8°C. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
Conjugation Unconjugated

How to select the appropriate detection channel through the spectrogram?

Background

CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Protocols & Troubleshootings

Related Protocols Staining Cell Surface Targets for Flow Cytometry
Troubleshooting

Troubleshooting for Flow Cytometry

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