Current Position:Home>>Antibodies>>FCM Antibodies>> Purified Anti-Human CD279/PD-1 Antibody[J110] E-AB-F1213A
|Alternate Names||PDCD1,PD1,Protein PD-1,hPD-1|
1.Zahn R, et al. 2008. J Virol. 82:11577. PubMed
2.Vojnov L, et al. 2010. J Virol. 84:753. PubMed
3.Conrad J, et al. 2011. J Immunol. 186:6871. PubMed
4.Monteiro P, et al. 2011. J Immunol. 186:4618. PubMed
5.Conrad J, et al. 2012. J Virol. 86:4213. PubMed
6.Nicholas K, et al. 2015. Cytometry A. 10.1002/cyto.a.22799. PubMed
7.Chevrier S, et al. 2017. Cell. 169:736. PubMed
8.Martín-Gayo E, et al. 2017. JCI Insight. 2:e89574. PubMed
|Clone No.||J110(See Other Available Formats)|
|Isotype||Mouse IgG1, κ|
|Isotype Control||Purified Mouse IgG1, κ Isotype Control[MOPC-21] [Product E-AB-F09793A]|
|Application||FCM, IHC (See the Application Description)|
|Storage Buffer||PBS with 0.05% Proclin300|
|Recommended Use||Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 g per 106 cells in 100 μL volume or 100 μL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.|
|Shipping||Biological ice pack at 4℃|
|Stability & Storage||Keep as concentrated solution.
Store at 2~8℃. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
|Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.|
|Related Protocols||Staining Cell Surface Targets for Flow Cytometry|
|E-AB-F12130||AF/LE Purified Anti-Human CD279/PD-1 Antibody[J110] E-AB-F12130||50 μg, 500 μg, 1 mg|
|E-AB-F1213A||Purified Anti-Human CD279/PD-1 Antibody[J110] E-AB-F1213A||25 μg, 100 μg|