Purified Anti-Human CD279/PD-1 Antibody[J110] E-AB-F1213A

Uniprot : P20701
  • Host: Mouse
  • Applications: FCM, IHC
  • Isotype: Mouse IgG1, κ

To Purchase E-AB-F1213A

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  • 25 μg
  • 100 μg
Price: $35
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Antigen Details

Alternate Names PDCD1,PD1,Protein PD-1,hPD-1
Swissprot P20701
References
1.Zahn R, et al. 2008. J Virol. 82:11577. PubMed
2.Vojnov L, et al. 2010. J Virol. 84:753. PubMed
3.Conrad J, et al. 2011. J Immunol. 186:6871. PubMed
4.Monteiro P, et al. 2011. J Immunol. 186:4618. PubMed
5.Conrad J, et al. 2012. J Virol. 86:4213. PubMed
6.Nicholas K, et al. 2015. Cytometry A. 10.1002/cyto.a.22799. PubMed
7.Chevrier S, et al. 2017. Cell. 169:736. PubMed
8.Martín-Gayo E, et al. 2017. JCI Insight. 2:e89574. PubMed

Product Details

Form Liquid
Clone No. J110(See Other Available Formats)
Host Mouse
Isotype Mouse IgG1, κ
Isotype Control Purified Mouse IgG1, κ Isotype Control[MOPC-21] [Product E-AB-F09793A]
Reactivity Human
Application FCM, IHC (See the Application Description)
Storage Buffer PBS with 0.05% Proclin300
Recommended Use Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 g per 106 cells in 100 μL volume or 100 μL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Shipping Biological ice pack at 4℃
Stability & Storage Keep as concentrated solution.
Store at 2~8℃. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
Conjugation Unconjugated

Background

Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Protocols & Troubleshootings

Related Protocols Staining Cell Surface Targets for Flow Cytometry
Troubleshooting

Troubleshooting for Flow Cytometry

Alternative Formats

Cat.No. Product Name Sizes
E-AB-F12130 AF/LE Purified Anti-Human CD279/PD-1 Antibody[J110] E-AB-F12130 50 μg, 500 μg, 1 mg
E-AB-F1213A Purified Anti-Human CD279/PD-1 Antibody[J110] E-AB-F1213A 25 μg, 100 μg

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