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Rat INS(Insulin) ELISA Kit

Citations(122)Uniprot : P01322,P01323

  • Cat.No.:E-EL-R3034

  • Reactivity: Rat
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Manual MSDS

To Purchase E-EL-R3034

Size:
  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $609
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Product Details

Properties

Assay type Sandwich-ELISA
Format 96T/48T
Assay time 3.5h
Detection range 6.25-400 pg/mL
Sensitivity 3.75 pg/mL
Sample type &Sample volume serum, plasma and other biological fluids; 100μL
Specificity This kit recognizes Rat INS in samples. No significant cross-reactivity or interference between Rat INS and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of Rat INS concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat INS. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Rat INS and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat INS, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Rat INS. You can calculate the concentration of Rat INS in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
ItemSpecificationsStorage
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips 		-20℃, 6 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL 		-20℃(Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Rat INS were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Rat INS were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 19.26 40.93 195.61 17.58 47.64 176.39
Standard deviation 0.98 1.86 8.22 1.05 2.19 7.37
CV (%) 5.09 4.54 4.20 5.97 4.60 4.18

Recovery

The recovery of Rat INS spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 86-99 94
EDTA plasma (n=8) 83-97 90

Linearity

Samples were spiked with high concentrations of Rat INS and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database LinksSwissProt:   P01322  P01323
SynonymsIDDM2, ILPR, IRDN, MODY10
Research AreaCancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction

Assay Procedures

elisa assay procedure 1

1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C
elisa assay procedure 2

2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C
elisa assay procedure 3

3. Aspirate and wash the plate for 3 times
elisa assay procedure 4

4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times
elisa assay procedure 5

5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C
elisa assay procedure 6

6. Add 50μL Stop Solution
elisa assay procedure 7

7. Read the plate at 450nm immediately. Calculation of the results

Citations

  1. Antioxidants (2022) IF: 7.675
    Therapeutic Effects of Heterotrigona itama (Stingless Bee) Bee Bread in Improving Hepatic Lipid Metabolism through theActivation of the Keap1/Nrf2 Signaling Pathway in an Obese Rat Model

    DOI: 10.3390/antiox11112190
    Sample: serum
  2. Antioxidants (2022) IF: 7.675
    Kelulut Honey Ameliorates Oestrus Cycle, Hormonal Profiles, and Oxidative Stress in Letrozole-Induced Polycystic Ovary Syndrome Rats

    DOI: 10.3390/antiox11101879

    PMID: 36290602

    		 Sample: serum
  3. Frontiers in Endocrinology (2022) IF: 6.055
    Investigating the Effects of Diet-Induced Pre-Diabetes on the Functioning of Calcium-Regulating Organs in Male Sprague Dawley Rats: Effects on Selected Markers

    DOI: 10.3389/fendo.2022.914189

    PMID: 35898447

    		 Sample: plasma
  4. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022) IF: 6.208
    SEPT9 Upregulation in Satellite Glial Cells Associated with Diabetic Polyneuropathy in a Type 2 Diabetes-like Rat Model

    DOI: 10.3390/ijms23169372

    PMID: 36012625

    		 Sample: serum
  5. Antioxidants (2021) IF: 6.313
    Hepatoprotective Effect of Bee Bread in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Rats: Impact on Oxidative Stress and Inflammation

    DOI: 10.3390/antiox10122031

    PMID: 34943134

    		 Sample: serum
  6. Food & Function (2023) IF: 6.317
    Conjugated linoleic acid alleviates glycolipid metabolic disorders by modulating intestinal microbiota and short-chain fatty acids in obese rats

    DOI: 10.1039/D2FO03760B
    Sample: serum
  7. Journal of Materials Chemistry B (2022) IF: 6.331
    Grafting Resveratrol onto Mesoporous Silica Nanoparticles towards Efficient Sustainable Immunoregulation and Insulin Resistance Alleviation for Diabetic Periodontitis Therapy

    DOI: 10.1039/D2TB00484D

    PMID: 35678150

    		 Sample: plasma
  8. International Journal of Nanomedicine (2021) IF: 6.4
    Development and Evaluation of Curcumin Encapsulated Self-assembled Nanoparticles as Potential Remedial Treatment for PCOS in a Female Rat Model

    DOI: 10.2147/IJN.S302161

    PMID: 34531655

    		 Sample: serum
  9. FOOD RESEARCH INTERNATIONAL (2022) IF: 6.475
    Acrylamide induced glucose metabolism disorder in rats involves gut microbiota dysbiosis and changed bile acids metabolism

    DOI: 10.1016/j.foodres.2022.111405

    PMID: 35761659

    		 Sample: serum
  10. BIOMEDICINE & PHARMACOTHERAPY (2021) IF: 6.53
    D-ribose-L-cysteine prevents oxidative stress and cardiometabolic syndrome in high fructose high fat diet fed rats

    DOI: 10.1016/j.biopha.2021.112017

    PMID: 34399203

    		 Sample: serum
  11. BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
    Diacerein ameliorates letrozole-induced polycystic ovarian syndrome in rats

    DOI: 10.1016/j.biopha.2022.112870

    PMID: 35367769

    		 Sample: serum
  12. Oxidative Medicine and Cellular Longevity (2021) IF: 6.543
    Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS-Like Rats

    DOI: 10.1155/2021/7382900
    Sample: serum
  13. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021) IF: 6.953
    Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation

    DOI: 10.1016/j.ijbiomac.2021.05.066

    PMID: 33992651

    		 Sample: Serum
  14. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2022) IF: 5.011
    Acetate: A therapeutic candidate against renal disorder in a rat model of polycystic ovarian syndrome

    DOI: 10.1016/j.jsbmb.2022.106179

    PMID: 36150640

    		 Sample: plasma
  15. LIFE SCIENCES (2022) IF: 5.037
    sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes

    DOI: 10.1016/j.lfs.2022.120438

    PMID: 35227772

    		 Sample: serum
  16. LIFE SCIENCES (2021) IF: 5.037
    Pancreastatin mediated regulation of UCP-1 and energy expenditure in high fructose fed perimenopausal rats

    DOI: 10.1016/j.lfs.2021.119677

    PMID: 34081990

    		 Sample: Serum
  17. JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 5.195
    Senna petersiana (Bolle) leaf extract modulates glycemic homeostasis and improves dysregulated enzyme activities in fructose-fed streptozotocin-induced diabetic rats

    DOI: 10.1016/j.jep.2022.115998
    Sample: serum
  18. EUROPEAN JOURNAL OF PHARMACOLOGY (2023) IF: 5.195
    Pancreastatin inhibitor PSTi8 ameliorates streptozotocin-induced diabetes by suppressing hepatic glucose production

    DOI: 10.1016/j.ejphar.2023.175559
    Sample: plasma
  19. JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 5.195
    Antidiabetic effects of Psidium x durbanensis Baijnath & Ramcharun ined. (Myrtaceae) leaf extract on streptozotocin-induced diabetes in rats

    DOI: 10.1016/j.jep.2022.115542

    PMID: 35842177

    		 Sample: plasma
  20. Scientific Reports (2016) IF: 5.228
    FGF21 ameliorates the neurocontrol of blood pressure in the high fructose-drinking rats

    DOI: 10.1038/srep29582
    Sample: Serum
  21. Frontiers in Cellular and Infection Microbiology (2021) IF: 5.293
    Alleviation Effects of GQD, a Traditional Chinese Medicine Formula, on Diabetes Rats Linked to Modulation of the Gut Microbiome

    DOI: 10.3389/fcimb.2021.740236
    Sample: serum
  22. Journal of Materials Chemistry B (2020) IF: 5.344
    A sustained zero-order release carrier for long-acting, peakless basal insulin therapy

    DOI: 10.1039/C9TB02728A

    PMID: 32067015

    		 Sample: Plasma
  23. Journal of Materials Chemistry B (2020) IF: 5.344
    A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation

    DOI: 10.1039/D0TB00561D

    PMID: 32373901

    		 Sample: Plasma
  24. Journal of Ovarian Research (2022) IF: 5.506
    GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway

    DOI: 10.1186/s13048-022-01092-z
    Sample: serum
  25. Frontiers in Pharmacology (2021) IF: 5.811
    Anti-Obesity and Lipid Lowering Activity of Bauhiniastatin-1 is Mediated Through PPAR-γ/AMPK Expressions in Diet-Induced Obese Rat Model

    DOI: 10.3389/fphar.2021.704074
    Sample: Serum
  26. MOLECULAR NUTRITION & FOOD RESEARCH (2021) IF: 5.82
    Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model

    DOI: 10.1002/mnfr.202001133

    PMID: 33548087

    		 Sample: Serum
  27. Frontiers in Pharmacology (2022) IF: 5.988
    Study on the mechanism of American ginseng extract for treating type 2 diabetes mellitus based on metabolomics.

    DOI: 10.3389/fphar.2022.960050
    Sample: serum
  28. Journal of Diabetes Research (2022) IF: 4.061
    Topical Application of Chinese Formula Yeliangen Promotes Wound Healing in Streptozotocin-Induced Diabetic Rats

    DOI: 10.1155/2022/1193392
    Sample: serum
  29. CARDIOVASCULAR DRUGS AND THERAPY (2020) IF: 4.069
    Titin and CK2α are New Intracellular Targets in Acute Insulin Application-Associated Benefits on Electrophysiological Parameters of Left Ventricular Cardiomyocytes From Insulin-Resistant Metabolic Syndrome Rats

    DOI: 10.1007/s10557-020-06974-2

    PMID: 32377826

    		 Sample: Serum
  30. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2021) IF: 4.076
    Vanillin improves glucose homeostasis and modulates metabolic activities linked to type 2 diabetes in fructose–streptozotocin induced diabetic rats

    DOI: 10.1080/13813455.2021.1988981
    Sample: Serum
  31. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2021) IF: 4.076
    Ezetimibe attenuates experimental diabetes and renal pathologies via targeting the advanced glycation, oxidative stress and AGE-RAGE signalling in rats

    DOI: 10.1080/13813455.2021.1874996

    PMID: 33508970

    		 Sample: Plasma
  32. BIOLOGICAL TRACE ELEMENT RESEARCH (2023) IF: 4.081
    Therapeutic Potential of Selenium Nanoparticles on Letrozole-Induced Polycystic Ovarian Syndrome in Female Wistar Rats

    DOI: 10.1007/s12011-023-03579-2
    Sample: Serum
  33. ACS Omega (2022) IF: 4.132
    Comparative Biochemical Profiling of Aluminum Chloride and Sodium Azide Induced Neuroinflammation and Cardiometabolic Disturbance

    DOI: 10.1021/acsomega.2c05467

    PMID: 36385866

    		 Sample: serum
  34. Drug Design Development and Therapy (2021) IF: 4.162
    Maackiain Protects the Kidneys of Type 2 Diabetic Rats via Modulating the Nrf2/HO-1 and TLR4/NF-κB/Caspase-3 Pathways

    DOI: 10.2147/DDDT.S326975

    PMID: 34703210

    		 Sample: serum
  35. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020) IF: 4.192
    Effects of Casein, Chicken, and Pork Proteins on the Regulation of Body Fat and Blood Inflammatory Factors and Metabolite Patterns Are Largely Dependent on the Protein Level and Less Attributable to the Protein Source

    DOI: 10.1021/acs.jafc.0c03337

    PMID: 32797752

    		 Sample: Serum
  36. Journal of Traditional and Complementary Medicine (2016) IF: 4.221
    Incretin effect of Urena lobata leaves extract on structure and function of rats islet β-cells

    DOI: 10.1016/j.jtcme.2016.10.001
    Sample: serum
  37. Journal of Traditional and Complementary Medicine (2021) IF: 4.221
    Chromatographic fractions from Chrysophyllum albidum stem bark boost antioxidant enzyme activity and ameliorate some markers of diabetes complications

    DOI: 10.1016/j.jtcme.2021.01.005
    Sample: serum
  38. Journal of Diabetes Investigation (2021) IF: 4.232
    Diet-induced prediabetes: Effects on the activity of the renin-angiotensin-aldosterone system (RAAS) in selected organs

    DOI: 10.1111/jdi.13690
    Sample: plasma
  39. Food Bioscience (2021) IF: 4.24
    Biosynthesis of magnesium hydroxide nanomaterials using Monodora myristica, antioxidative activities and effect on disrupted glucose metabolism in streptozotocin-induced diabetic rat

    DOI: 10.1016/j.fbio.2021.101023
    Sample: Serum
  40. Neuroscience Bulletin (2019) IF: 4.246
    Multi-molecular Targeting

    DOI: 10.1007/s12264-018-00336-7
    Sample: Plasma
  41. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021) IF: 4.31
    Bee bread mitigates downregulation of steroidogenic genes, decreased spermatogenesis, and epididymal oxidative stress in male rats fed with high-fat diet

    DOI: 10.1152/ajpendo.00093.2021

    PMID: 34229480

    		 Sample: serum,testis
  42. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Hypoglycemic and hypolipidemic effects of total glycosides of Cistanche tubulosa in diet/streptozotocin-induced diabetic rats

    DOI: 10.1016/j.jep.2021.113991

    PMID: 33675914

    		 Sample: Serum
  43. Scientific Reports (2022) IF: 4.38
    Gold nanoclusters eliminate obesity induced by antipsychotics

    DOI: 10.1038/s41598-022-09541-x
    Sample: plasma
  44. SAUDI PHARMACEUTICAL JOURNAL (2023) IF: 4.562
    6-gingerol ameliorates weight gain and insulin resistance in metabolic syndrome rats by regulating adipocytokines

    DOI: 10.1016/j.jsps.2023.01.003
    Sample: Serum
  45. JOURNAL OF MOLECULAR MEDICINE-JMM (2022) IF: 4.599
    PTEN-induced kinase 1 deficiency alters albumin permeability and insulin signaling in podocytes

    DOI: 10.1007/s00109-022-02204-4

    PMID: 35534645

    		 Sample: serum
  46. International Journal of Environmental Research and Public Health (2022) IF: 4.614
    Effects of an Exercise Program Combining Aerobic and Resistance Training on Protein Expressions of Neurotrophic Factors in Obese Rats Injected with Beta-Amyloid

    DOI: 10.3390/ijerph19137921

    PMID: 35805580

    		 Sample: plasma
  47. Stem Cell Research & Therapy (2019) IF: 4.627
    Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats

    DOI: 10.1186/s13287-019-1474-8

    PMID: 31747961

    		 Sample: Serum
  48. NUTRITION (2022) IF: 4.893
    Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3

    DOI: 10.1016/j.nut.2022.111914
    Sample: plasma
  49. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020) IF: 3
    Role of glucocorticoid receptor phosphorylation-mediated synaptic plasticity in anxiogenic and depressive behaviors induced by monosodium glutamate

    DOI: 10.1007/s00210-020-01845-x

    PMID: 32444989

    		 Sample: Serum
  50. PeerJ (2022) IF: 3.061
    Effects of combination of obesity, diabetes, and hypoxia on inflammatory regulating genes and cytokines in rat pancreatic tissues and serum

    DOI: 10.7717/peerj.13990

    PMID: 36213511

    		 Sample: serum
  51. DIABETES-METABOLISM RESEARCH AND REVIEWS (2016) IF: 3.064
    Gut microbiota after Roux‐en‐Y gastric bypass and sleeve gastrectomy in a diabetic rat model: Increased diversity and associations of discriminant genera with metabolic changes

    DOI: 10.1002/dmrr.2857
    Sample: Serum
  52. ARTIFICIAL ORGANS (2021) IF: 3.094
    Hypothermic oxygenated perfusion with defatting cocktail further improves steatotic liver grafts in a transplantation rat model

    DOI: 10.1111/aor.13976
    Sample: serum
  53. KIDNEY & BLOOD PRESSURE RESEARCH (2017) IF: 3.104
    The Ameliorative Effect of Pectin-Insulin Patch On Renal Injury in Streptozotocin-Induced Diabetic Rats

    DOI: 10.1159/000480395
    Sample: Urine,Tissue homogenate,Plasma
  54. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2021) IF: 3.168
    The Effect of Rooibos (Aspalathus linearis), Honeybush (Cyclopia intermedia) and Sutherlandia (Lessertia frutescens) on Testicular Insulin Signalling in Streptozotocin-Induced Diabetes in Wistar Rats

    DOI: 10.2147/DMSO.S285025
    Sample: Plasma
  55. BMJ Open Diabetes Research & Care (2020) IF: 3.183
    Habenula lesions improve glucose metabolism in rats with type 2 diabetes by increasing insulin sensitivity and inhibiting gluconeogenesis

    DOI: 10.1136/bmjdrc-2020-001250

    PMID: 32393480

    		 Sample: Serum
  56. REPRODUCTION (2020) IF: 3.206
    Orlistat reverses intratesticular lactate transport decline and infertility in male obese rats

    DOI: 10.1530/REP-20-0381

    PMID: 33112813

    		 Sample: serum
  57. Nutrition & Metabolism (2020) IF: 3.211
    The dysregulation of the hypothalamic–pituitary–adrenal axis in diet-induced prediabetic male Sprague Dawley rats

    DOI: 10.1186/s12986-020-00532-1
    Sample: plasma
  58. HUMAN & EXPERIMENTAL TOXICOLOGY (2022) IF: 3.247
    Bisacurone attenuates diabetic nephropathy by ameliorating oxidative stress, inflammation and apoptosis in rats

    DOI: 10.1177/09603271221143713
    Sample: serum
  59. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2022) IF: 3.249
    Lingguizhugan Decoction Targets Intestinal Microbiota and Metabolites to Reduce Insulin Resistance in High-Fat Diet Rats

    DOI: 10.2147/DMSO.S370492

    PMID: 35971521

    		 Sample: serum
  60. EUROPEAN JOURNAL OF PHARMACOLOGY (2020) IF: 3.263
    Supplementation of pyrroloquinoline quinone with atorvastatin augments mitochondrial biogenesis and attenuates low grade inflammation in obese rats

    DOI: 10.1016/j.ejphar.2020.173273
    Sample: serum
  61. BMC Endocrine Disorders (2022) IF: 3.263
    Novel sedentary cage induced sedentariness in rats: evidence from relevant biomarkers

    DOI: 10.1186/s12902-022-01221-1
    Sample: serum
  62. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2020) IF: 3.292
    Chronic exposure of bisphenol A impairs carbohydrate and lipid metabolism by altering corresponding enzymatic and metabolic pathways

    DOI: 10.1016/j.etap.2020.103387

    PMID: 32339907

    		 Sample: Serum
  63. CELL TRANSPLANTATION (2020) IF: 3.341
    Bone Marrow-Derived Mesenchymal Stem Cells Restored High-Fat-Fed Induced Hyperinsulinemia in Rats at Early Stage of Type 2 Diabetes Mellitus:

    DOI: 10.1177/0963689720904628
    Sample: Serum,plasma
  64. RSC Advances (2021) IF: 3.361
    Metabolomic profiling to reveal the therapeutic potency of Posidonia oceanica nanoparticles in diabetic rats

    DOI: 10.1039/D0RA09606G
    Sample: Serum
  65. DISEASE MARKERS (2021) IF: 3.434
    The Roles of Liver Inflammation and the Insulin Signaling Pathway in PM2.5 Instillation-Induced Insulin Resistance in Wistar Rats

    DOI: 10.1155/2021/2821673

    PMID: 34745386

    		 Sample: serum
  66. BRAIN RESEARCH BULLETIN (2018) IF: 3.44
    Role of simvastatin and insulin in memory protection in a rat model of diabetes mellitus and dementia

    DOI: 10.1016/j.brainresbull.2018.10.012

    PMID: 30395886

    		 Sample: Serum
  67. LIFE SCIENCES (2019) IF: 3.448
    Inhibition of JAK-STAT and NF-κB signalling systems could be a novel therapeutic target against insulin resistance and type 2 diabetes

    DOI: 10.1016/j.lfs.2019.117045

    PMID: 31730866

    		 Sample: Serum
  68. LIFE SCIENCES (2019) IF: 3.448
    Effects of noopept on cognitive functions and pubertal process in rats with diabetes

    DOI: 10.1016/j.lfs.2019.116698

    PMID: 31356906

    		 Sample: Serum,Tissue homogenate
  69. BIOMEDICINE & PHARMACOTHERAPY (2018) IF: 3.457
    Tangganjian decoction ameliorates type 2 diabetes mellitus and nonalcoholic fatty liver disease in rats by activating the IRS/PI3K/AKT signaling pathway

    DOI: 10.1016/j.biopha.2018.06.089
    Sample: Serum
  70. Nutrition & Metabolism (2018) IF: 3.483
    The protective effect of neonatal oral administration of oleanolic acid against the subsequent development of fructose-induced metabolic dysfunction in male and female rats

    DOI: 10.1186/s12986-018-0314-7
    Sample: plasma
  71. Frontiers in Neural Circuits (2021) IF: 3.492
    Excitatory Impact of Dental Occlusion on Dorsal Motor Nucleus of Vagus

    DOI: 10.3389/fncir.2021.638000

    PMID: 33776655

    		 Sample: Serum
  72. Nutrients (2017) IF: 3.55
    Phyllanthus Niruri Standardized Extract Alleviates the Progression of Non-Alcoholic Fatty Liver Disease and Decreases Atherosclerotic Risk in Sprague–Dawley Rats

    DOI: 10.3390/nu9070766
    Sample: Serum
  73. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019) IF: 3.571
    Antiobesity Effect of Flaxseed Polysaccharide via Inducing Satiety due to Leptin Resistance Removal and Promoting Lipid Metabolism through the AMP-Activated Protein Kinase (AMPK) Signaling Pathway

    DOI: 10.1021/acs.jafc.9b02434
    Sample: serum
  74. LIFE SCIENCES (2020) IF: 3.647
    Ileal interposition improves metabolic syndrome parameters in a rat model of metabolic syndrome induced by monosodium glutamate

    DOI: 10.1016/j.lfs.2020.118846

    PMID: 33309719

    		 Sample: Plasma
  75. BMC Complementary and Alternative Medicine (2022) IF: 3.659
    Attenuation of carbohydrate metabolism and lipid profile by methanolic extract of Euphorbia helioscopia and improvement of beta cell function in a type 2 diabetic rat model

    DOI: 10.1186/s12906-022-03507-2

    PMID: 35078449

    		 Sample: serum
  76. JOURNAL OF PHARMACY AND PHARMACOLOGY (2022) IF: 3.765
    Caffeic acid regulates glucose homeostasis and inhibits purinergic and cholinergic activities while abating oxidative stress and dyslipidaemia in fructose-streptozotocin-induced diabetic rats

    DOI: 10.1093/jpp/rgac021

    PMID: 35640634

    		 Sample: serum
  77. Heliyon (2019) IF: 3.776
    Adverse effects of noise stress on glucose homeostasis and insulin resistance in Sprague-Dawley rats

    DOI: 10.1016/j.heliyon.2019.e03004

    PMID: 31890958

    		 Sample: Serum
  78. EXPERIMENTAL CELL RESEARCH (2021) IF: 3.905
    Hyperglycemia alters mitochondrial respiration efficiency and mitophagy in human podocytes

    DOI: 10.1016/j.yexcr.2021.112758

    PMID: 34437881

    		 Sample: serum
  79. Scientific Reports (2020) IF: 3.998
    Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses

    DOI: 10.1038/s41598-020-63498-3
    Sample: serum
  80. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020) IF: 2.05
    Possible mechanisms mediating the protective effect of cilostazol in L-arginine induced acute pancreatitis in rats: role of cGMP, cAMP, and HO-1

    DOI: 10.1007/s00210-020-01897-z

    PMID: 32424476

    		 Sample: Serum
  81. Journal of Developmental Origins of Health and Disease (2017) IF: 2.07
    Effect of neonatal orally administered S-allyl cysteine in high-fructose diet fed Wistar rats

    DOI: 10.1017/S2040174417000940
    Sample: Plasma
  82. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2019) IF: 2.11
    Evaluating the effects of Juglans regia L. extract on hyperglycaemia and insulin sensitivity in experimental type 2 diabetes in rat

    DOI: 10.1080/13813455.2019.1668018
    Sample: Plasma
  83. Journal of Diabetes Research (2015) IF: 2.164
    Edible Bird’s Nest Prevents High Fat Diet-Induced Insulin Resistance in Rats

    DOI: 10.1155/2015/760535
    Sample: Serum
  84. Islets (2017) IF: 2.2
    The adverse effects of chronic low-dose exposure to nonylphenol on type 2 diabetes mellitus in high sucrose-high fat diet-treated rats

    DOI: 10.1080/19382014.2017.1404211
    Sample: Plasma
  85. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2018) IF: 2.21
    The pectin–insulin patch application prevents the onset of peripheral neuropathy-like symptoms in streptozotocin-induced diabetic rats

    DOI: 10.1139/cjpp-2018-0415
    Sample: Plasma
  86. EXPERIMENTAL BIOLOGY AND MEDICINE (2014) IF: 2.226
    Perivascular adipose tissue-derived leptin promotes vascular smooth muscle cell phenotypic switching via p38 mitogen-activated protein kinase in metabolic syndrome rats:

    DOI: 10.1177/1535370214527903
    Sample: Plasma
  87. Veterinary Sciences (2022) IF: 2.304
    Time-Restricted Feeding Improved Vascular Endothelial Function in a High-Fat Diet-Induced Obesity Rat Model

    DOI: 10.3390/vetsci9050217

    PMID: 35622745

    		 Sample: serum
  88. Veterinary Sciences (2021) IF: 2.304
    Protective and Therapeutic Effects of Orlistat on Metabolic Syndrome and Oxidative Stress in High-Fat Diet-Induced Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Rats: Role on Nrf2 Activation

    DOI: 10.3390/vetsci8110274
  89. PeerJ (2019) IF: 2.353
    Cafeteria diet increased adiposity in comparison to high fat diet in young male rats

    DOI: 10.7717/peerj.6656
    Sample: plasma
  90. International Journal of Endocrinology (2016) IF: 2.376
    4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis

    DOI: 10.1155/2016/4592346
    Sample: Serum
  91. Integrative Medicine Research (2019) IF: 2.379
    Orthosiphon stamineus as a potential antidiabetic drug in maternal hyperglycemia in streptozotocin-induced diabetic rats

    DOI: 10.1016/j.imr.2019.05.006
    Sample: plasma
  92. METABOLIC BRAIN DISEASE (2019) IF: 2.411
    High fat-low protein diet induces metabolic alterations and cognitive dysfunction in female rats

    DOI: 10.1007/s11011-019-00459-4
    Sample: serum
  93. EXPERIMENTAL AND MOLECULAR PATHOLOGY (2017) IF: 2.423
    Effects of single or combined induction of diabetes mellitus and knee osteoarthritis on some biochemical and haematological parameters in rats

    DOI: 10.1016/j.yexmp.2017.07.005
    Sample: Serum
  94. Journal of Diabetes Research (2016) IF: 2.431
    IL-6 Promotes Islet β-Cell Dysfunction in Rat Collagen-Induced Arthritis

    DOI: 10.1155/2016/7592931
    Sample: Plasma
  95. Experimental and Therapeutic Medicine (2021) IF: 2.447
    Double‑lobectomy in a steatotic liver transplantation rat model

    DOI: 10.3892/etm.2021.9687
    Sample: Serum
  96. Journal of Developmental Origins of Health and Disease (2020) IF: 2.456
    Neonatal zingerone protects against the development of high-fructose diet-induced metabolic syndrome in adult Sprague-Dawley rats

    DOI: 10.1017/S2040174420000525
    Sample: plasma
  97. International Journal of Environmental Research and Public Health (2019) IF: 2.468
    The Beneficial Effects of Stingless Bee Honey from Heterotrigona itama against Metabolic Changes in Rats Fed with High-Carbohydrate and High-Fat Diet

    DOI: 10.3390/ijerph16244987

    PMID: 31817937

    		 Sample: Serum
  98. Journal of Ovarian Research (2019) IF: 2.469
    Abnormal expression of HSP70 may contribute to PCOS pathology

    DOI: 10.1186/s13048-019-0548-7
    Sample: serum
  99. ANDROLOGIA (2023) IF: 2.532
    Resveratrol Mitigates Diabetic Testicular Dysfunction, Endocrine Deficits, and Insulin Resistance via Suppression of Sperm-Endocrine Aberrations and Oxidative Inflammation in Rats

    DOI: 10.1155/2023/6385767
    Sample: serum
  100. DRUG DELIVERY (2015) IF: 2.558
    Enhanced oral bioavailability of insulin using PLGA nanoparticles co-modified with cell-penetrating peptides and Engrailed secretion peptide (Sec)

    DOI: 10.3109/10717544.2015.1043472
    Sample: Plasma
  101. JOURNAL OF PHARMACY AND PHARMACOLOGY (2020) IF: 2.571
    Tropisetron improves pancreas function and increases insulin synthesis and secretion in the STZ‐induced diabetic rats: involvement of UCP2/ZnT8 pathway

    DOI: 10.1111/jphp.13278
    Sample: Serum
  102. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2020) IF: 2.575
    Angiotensin converting enzyme inhibitor potentiates the hypoglycaemic effect of NG-nitro-L-arginine methyl ester (L-NAME) in rats

    DOI: 10.1080/13813455.2020.1780263

    PMID: 32584611

    		 Sample: Serum
  103. Dose-Response (2022) IF: 2.623
    Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion :

    DOI: 10.1177/15593258221114184
    Sample: serum
  104. PEDIATRIC RESEARCH (2020) IF: 2.747
    Postnatal overfeeding induces hepatic microRNA-221 expression and impairs the PI3K/AKT pathway in adult male rats

    DOI: 10.1038/s41390-020-0877-7
    Sample: serum
  105. FUNDAMENTAL & CLINICAL PHARMACOLOGY (2022) IF: 2.747
    Ferulic acid improves glucose homeostasis by modulation of key diabetogenic activities and restoration of pancreatic architecture in diabetic rats

    DOI: 10.1111/fcp.12860
    Sample: serum
  106. JOURNAL OF BIOMEDICAL SCIENCE (2015) IF: 2.763
    High fat diet-induced inflammation and oxidative stress are attenuated by N-acetylneuraminic acid in rats

    DOI: 10.1186/s12929-015-0211-6
    Sample: Serum
  107. GLYCOCONJUGATE JOURNAL (2021) IF: 2.916
    Variations in the mRNA expression level of UDP-GlcNAc epimerase/ManNAc kinase and neuraminidase 1 genes in organs of type 2 diabetic animals

    DOI: 10.1007/s10719-021-09979-7

    PMID: 33608771

    		 Sample: Serum
  108. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019) IF: 2.928
    Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR

    DOI: 10.3892/ijmm.2018.3977

    PMID: 30431108

    		 Sample: Serum
  109. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019) IF: 2.928
    Green tea polyphenols attenuate hepatic steatosis, and reduce insulin resistance and inflammation in high-fat diet-induced rats

    DOI: 10.3892/ijmm.2019.4285
    Sample: blood
  110. Chinese Medicine (2020) IF: 2.96
    Protective effects of essential oil from Fructus Alpiniae zerumbet on retinal Müller gliosis via the PPAR-γ-p-CREB signaling pathway

    DOI: 10.1186/s13020-019-0283-4

    PMID: 31938037

    		 Sample: Serum,Cell culture medium
  111. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2019) IF: 2.977
    Insulin Resistance–Related Proteins Are Overexpressed in Patients and Rats Treated With Olanzapine and Are Reverted by Pueraria in the Rat Model

    DOI: 10.1097/JCP.0000000000001028
    Sample: Plasma
  112. SOUTH AFRICAN JOURNAL OF BOTANY (2019) IF: 1.504
    Moringa oleifera Lam. prevents the development of high fructose diet-induced fatty liver

    DOI: 10.1016/j.sajb.2018.12.003
    Sample: Serum
  113. Molecular Medicine Reports (2016) IF: 1.559
    Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

    DOI: 10.3892/mmr.2016.4823
    Sample: Serum
  114. Biomed Research International (2015) IF: 1.579
    N-Acetylneuraminic Acid Supplementation Prevents High Fat Diet-Induced Insulin Resistance in Rats through Transcriptional and Nontranscriptional Mechanisms

    DOI: 10.1155/2015/602313
    Sample: Serum
  115. BIOLOGIA (2022) IF: 1.653
    The effects of β-escin on inflammation, oxidative stress and Langerhans islet cells in high-fat diet and streptozotocin injection induced experimental type-2 diabetes model

    DOI: 10.1007/s11756-022-01266-6
    Sample: serum
  116. JOURNAL OF FOOD BIOCHEMISTRY (2020) IF: 1.662
    Cognitive impairment by non‐insulin‐dependent diabetes mellitus was attenuated by dietary supplements of marble vine (Dioclea reflexa) and plantain (Musa paradisiaca) dough meals in albino rats

    DOI: 10.1111/jfbc.13473
    Sample: Plasma
  117. BIOTECHNIC & HISTOCHEMISTRY (2021) IF: 1.718
    Short term effects of experimental gastric outlet obstruction and truncal vagotomy on gut hormones

    DOI: 10.1080/10520295.2021.1896780

    PMID: 33722110

    		 Sample: serum
  118. ACTA CARDIOLOGICA (2022) IF: 1.718
    AMPK/mTOR-mediated therapeutic effect of metformin on myocardial ischaemia reperfusion injury in diabetic rat

    DOI: 10.1080/00015385.2021.2024701

    PMID: 34994666

    		 Sample: serum
  119. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2017) IF: 1.822
    Onset of decreased heart work is correlated with increased heart rate and shortened QT interval in high-carbohydrate fed overweight rats1

    DOI: 10.1139/cjpp-2017-0054
    Sample: Serum
  120. Iranian Journal of Basic Medical Sciences (2019) IF: 1.854
    Pterocarpus santalinus ameliorates streptozotocin-induced diabetes mellitus via anti-inflammatory pathways and enhancement of insulin function.

    DOI: 10.22038/ijbms.2019.34998.8325
    Sample: serum
  121. Scientific African (2021)
    Adverse effects of perinatal protein restriction on glucose homeostasis in offspring of Sprague-Dawley rats

    DOI: 10.1016/j.sciaf.2021.e01036
    Sample: serum
  122. Ulusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery (2022) IF: 0.894
    Intraductal botulinum toxin injection suppressed the inflammation in experimental acute pancreatitis.

    DOI: 10.14744/tjtes.2021.90140
    Sample: blood
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