Elab Fluor® 700 Anti-Mouse Foxp3 Antibody[3G3] (E-AB-F1238M1)
![Elab Fluor<sup>®</sup> 700 Anti-Mouse Foxp3 Antibody[3G3] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: Elab Fluor®700
APC Elab Fluor®700 FITC PE Unconjugated Show More
| Isotype | Mouse IgG1, κ |
| Host | Mouse |
| Reactivity | Mouse |
| Applications | FCM |
| Clonality | Monoclonal |
| Abbre | Foxp3 |
| Synonyms | Forkhead box protein P3, Foxp3, IPEX, JM2 |
| Swissprot | |
| Cellular Localization | Nucleus |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Clone No. | 3G3 |
| Conjugation | Elab Fluor®700 |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
| background | Foxp3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of Foxp3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. Foxp3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of Foxp3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of Foxp3 have been reported: one (Foxp3) corresponding to the canonical full-length sequence; the other (Foxp3 δ2) lacking exon 2. |
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