FITC Anti-Mouse Foxp3 Antibody[3G3] (E-AB-F1238C)
![FITC Anti-Mouse Foxp3 Antibody[3G3] - 1](http://file.elabscience.com/assets/images/loading.png)
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For research use only.
Conjugation: FITC
| Isotype | Mouse IgG1, κ |
| Host | Mouse |
| Reactivity | Mouse |
| Applications | ICFCM |
| Clonality | Monoclonal |
| Isotype Control | FITC Mouse IgG1, κ Isotype Control[MOPC-21] |
| Abbre | Foxp3 |
| Synonyms | Forkhead box protein P3, Foxp3, IPEX, JM2 |
| Swissprot | |
| Cellular Localization | Nucleus |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Immunology |
| Clone No. | 3G3 |
| Conjugation | FITC |
| Conjugation Information | FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter). |
| Spectrum |
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| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
| background | FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. |
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