FITC Anti-Human CD74 Antibody[LN2]

All	Size	Price	Qty
	100Tests	$ 190.00
	20Tests	$ 75.00
	100Tests×2	$ 285.00

Alternate Names	CD74, DHLAG, HLA class II histocompatibility antigen gamma chain, Ia antigen-associated invariant chain, Ii, p33
Clone No	LN2
Leadtime	Order now, ship in 3 days
Background	CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.
Abbre	CD74
Swissprot	P04233
Host	Mouse
Reactivity	Human
Clonality	Monoclonal
Isotype	Mouse IgG1, κ
Isotype Control	E-AB-F09792C
Applications	FCM
Research Areas	Immunology
Cellular Localization	Membrane
Form	Liquid
Concentration	5 μL/Test
Conjugation	FITC
Conjugation Information	FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter).
Spectrum
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage	This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Expiration Date	12 months
Shipping	Ice bag

Cat.No.	Product Name	Sizes
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E-CK-A107	Cell Staining Buffer	500mL , 200mL , 100mL

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FITC Anti-Human CD74 Antibody[LN2] (E-AB-F1072C)

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