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100μg $ 154.00
25μg $ 63.00
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For research use only.

Alternate Names CD74,  DHLAG,  HLA class II histocompatibility antigen gamma chain,  Ia antigen-associated invariant chain,  Ii,  p33
Clone No
Leadtime Order now, ship in 3 days
Verified Samples Verified Samples in FCM: Human peripheral blood lymphocytes
Dilution FCM 2 μg/mL(1×105-5×105 cells)
Background CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.
Immunogen Recombinant Human CD74 protein
Abbre CD74
Swissprot
Host Mouse
Reactivity Human
Clonality Monoclonal
Purification Method >98%, Protein A/G purified
Isotype Mouse IgG1, κ
Applications
FCM
Research Areas Immunology
Concentration
≥ 1 mg/mL
Conjugation Unconjugated
Storage Buffer Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
Storage Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Expiration Date 12 months
Shipping Ice bag
Cat.No. Product Name Sizes
E-AB-F1072B Biotin Anti-Human CD74 Antibody[LN2] 100μg , 25μg
E-AB-F1072C FITC Anti-Human CD74 Antibody[LN2] 100Tests , 20Tests , 100Tests×2
E-AB-F1072D PE Anti-Human CD74 Antibody[LN2] 100Tests , 20Tests , 100Tests×2
E-AB-F1072E APC Anti-Human CD74 Antibody[LN2] 100Tests , 20Tests , 100Tests×2
E-AB-F1072G PE/Cyanine5 Anti-Human CD74 Antibody[LN2] 100Tests , 20Tests , 100Tests×2
E-AB-F1072H PE/Cyanine7 Anti-Human CD74 Antibody[LN2] 100Tests , 20Tests , 100Tests×2
E-AB-F1072I PE/Cyanine5.5 Anti-Human CD74 Antibody[LN2] 100Tests , 20Tests , 100Tests×2
E-AB-F1072J PerCP/Cyanine5.5 Anti-Human CD74 Antibody[LN2] 100Tests , 20Tests , 100Tests×2
E-AB-F1072L Elab Fluor® 488 Anti-Human CD74 Antibody[LN2] 100Tests , 20Tests , 100Tests×2
E-AB-F1072M Elab Fluor® 647 Anti-Human CD74 Antibody[LN2] 100Tests , 20Tests , 100Tests×2
E-AB-F1072P PE/Elab Fluor® 594 Anti-Human CD74 Antibody[LN2] 100Tests , 20Tests , 100Tests×2
Other Clones

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Other Formats

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APC

Biotin

Elab Fluor®488

Elab Fluor®647

Elab Fluor®700

FITC

PE

PE/Cyanine 5

PE/Cyanine 5.5

PE/Cyanine 7

PE/Elab Fluor®594

PerCP/Cyanine 5.5

Unconjugated

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