PE Anti-Mouse IL-17A Antibody[TC11-18H10.1] (E-AB-F1199D)
![PE Anti-Mouse IL-17A Antibody[TC11-18H10.1] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: PE
APC Biotin Elab Fluor®647 FITC None (AF/LE) PE Unconjugated Show More
| Isotype | Rat IgG1, κ |
| Host | Rat |
| Reactivity | Mouse |
| Applications | ICFCM |
| Clonality | Monoclonal |
| Abbre | IL-17A |
| Synonyms | CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, Interleukin-17A |
| Swissprot | |
| Cellular Localization | Secreted |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Cell Biology, Immunology, Neuroinflammation, Neuroscience |
| Clone No. | TC11-18H10.1 |
| Conjugation | PE |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
| background | IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. |
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