Purified Anti-Human CD172a/b Antibody[SE5A5] (AN003170P)
![Purified Anti-Human CD172a/b Antibody[SE5A5] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: Unconjugated
APC Elab Fluor®700 FITC PE PerCP/Cyanine 5.5 Unconjugated Show More
| Verified Samples | Verified Samples in FCM: Human peripheral blood Granulocytes |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Isotype | Mouse IgG1, κ |
| Host | Mouse |
| Reactivity | Human |
| Applications | FCM |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human CD172a/b protein |
| Abbre | CD172a/b |
| Synonyms | Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs, CD172 Antigen-Like Family Member A, Inhibitory Feceptor SHPS-1, Macrophage Fusion Receptor, MyD-1 Antig, MyD-1 Antigen, SHP Substrate 1, SHPS-1, Signal-Regulatory Protein Alpha-1, Signal-Regulatory Protein Alpha-2, Signal-Regulatory Protein Alpha-3, Sirp-Alpha-1, Sirp-Alpha-2, Sirp-Alpha-3, Tyrosine-protein phosphatase non-receptor type substrate 1, COX, SHPS, Mtco, PTPNS, MT-CO, MYD, SIRPA, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP, MT-CO2, COII, COX2, COXII, MTCO2, MYD1, SIRP&, alpha |
| Swissprot | |
| Cellular Localization | Membrane |
| Tissue Specificity | Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. |
| Concentration | ≥ 1 mg/mL |
| Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Purification Method | >98%, Protein A/G purified |
| Research Areas | Neuroscience, Cardiovascular Biology, CDs, Neuron marker, Synapse marker |
| Clone | SE5A5 |
| Conjugation | Unconjugated |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | CD172a, also known as signal-regulatory protein α (SIRPα), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily and is primarily expressed on monocytes/macrophages, granulocytes, dendritic cells, and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion, and phagocytosis. CD47 (IAP) is the extracellular ligand for CD172a. SIRPα was recently demonstrated to be a specifc marker for cardiomyocytes derived from human pluripotent stem cells2. |
| Cat.No. | Product Name | Clone No. |
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