Purified Anti-Human CD244 Antibody[C1.7] (E-AB-F1374A)
![Purified Anti-Human CD244 Antibody[C1.7] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: Unconjugated
APC Elab Fluor®647 Elab Fluor®700 Elab Fluor®Violet 450 FITC PE PE/Cyanine 5 PE/Cyanine 7 Unconjugated Show More
| Alternate Names | 2B4, C9.1, CD244 antigen, CD244 molecule, CD244 molecule natural killer cell receptor 2B4, CD244 natural killer cell receptor 2B4, F730046O15Rik, Ly90, member 4, Natural killer cell activation-inducing ligand, NK cell activation inducing ligand, NK cell activation inducing ligand NAIL, NK cell type I receptor protein 2B4, Non-MHC restricted killing associated, OTTHUMP00000027884, p38, signaling lymphocytic activation molecule 4, SLAM family, h2B, SLAM family member, Natural killer cell receptor 2B, NKR2B, SLAMF, CD244, 2B4, NAIL, NKR2B4, Nmrk, SLAMF4, h2B4, Natural killer cell receptor 2B4, NK cell activation-inducing ligand, SLAM family member 4 |
| Clone | |
| Verified Samples | Verified Samples in FCM: Human peripheral blood lymphocytes |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Background | CD244, known as 2B4, is a 38 kD type I transmembrane protein. It is a member of the CD2 subset of the immunoglobulin superfamily (IgSF) molecules. CD244 is expressed on NK cells, a subset of T cells (including most CD8+ T cells and γ/δ T cells), monocytes, basophils, and eosinophils. CD48 is the ligand of CD244. It has been reported that ligation of human CD244 results in enhanced NK cell cytotoxicity and cytokine production. Recent studies have shown that human CD244, like murine CD244, has both activating and inhibitory functions, which are dependent on the density of surface 2B4 expression, degree of ligation, and the level of the adaptor molecule SAP expression. |
| Immunogen | Recombinant Human CD244 protein |
| Abbre | CD244 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21] |
| Applications |
FCM
|
| Research Areas | Immunology;Stem Cells;CDs;Hematopoietic Stem Cell Markers |
| Cellular Localization |
Cell membrane
|
| Tissue Specificity |
Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed in all natural killer (NK) cells, monocytes and basophils, TCR-gamma/delta+ T-cells, monocytes, basophils, and on a subset of CD8+ T-cells.
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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