Purified Anti-Human CD266 Antibody[ITEM-1] (AN008890P)
![Purified Anti-Human CD266 Antibody[ITEM-1] - 1](http://file.elabscience.com/assets/images/loading.png)
| Alternate Names | TNF receptor superfamily member 12A, tumor necrosis factor receptor superfamily member 12A, Fibroblast growth factor-inducible immediate-early response protein, TNFRSF12A, CD266, FN14, TWEAKR, Fibroblast growth factor-inducible immediate-early response protein 14, TWEAKRTNFRSF12A, TWEAK-R, Fn14, TNFRSF12a. |
| Clone | |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding human CD266 gene |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. Human and mouse TNFRSF12A share 82% aa sequence identity. TNFRSF12A transcript was expressed at high levels in heart, placenta, and kidney, at intermediate levels in lung, skeletal muscle, and pancreas, and at low levels in brain and liver. In addition, elevated TNFRSF12A expression was found in human liver cancer cell lines and hepatocellular carcinoma specimens. TNFRSF12A is the weak inducer of apoptosis in some cell types. It promotes angiogenesis and the proliferation of endothelial cells. TNFRSF12A may modulate cellular adhesion to matrix proteins. |
| Immunogen | Recombinant Human CD266 protein |
| Abbre | CD266 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21] |
| Applications |
FCM
|
| Research Areas | Signal Transduction;Cardiovascular Biology;Cancer;CDs;NF-kB Signaling Pathway;Angiogenesis |
| Cellular Localization |
Membrane
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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