Purified Anti-Human CD268 Antibody[H353-8H11] (AN007790P)

Name: Purified Anti-Human CD268 Antibody[H353-8H11]
Brand: Elabscience
SKU: AN007790P
Price: 63.0 USD
Availability: InStock

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Purified Anti-Human CD268 Antibody[H353-8H11] - 1

All	Size	Price	Qty
	100μg	$ 154.00	- +
	25μg	$ 63.00	- +

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Conjugation: Unconjugated

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Alternate Names	B cell activating factor receptor, BAFF receptor, BAFF receptor (BAFF-R), B-cell-activating factor receptor, BLyS receptor 3, BlySR3, BR 3, CD 268, CD268 antigen, MGC138235, OTTHUMP00000028746, TNFRSF 13C, TR13C, Tumor necrosis factor receptor subunit member 13C, CVID, TNFRSF13C, BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin, BAFF R, Tumor Necrosis Factor Receptor Superfamily Member 13C, BR3, BR3, TNFRSF13c
Clone	8H11
Verified Samples	Verified Samples in FCM: Human peripheral blood lymphocytes cell
Dilution	FCM ≤ 0.2 µg per million cells in 100 µL volume
Background	B-cell activating factor (BAFF), also known as BlyS, TALL-1, TNAK, and zTNF4, is a TNF ligand superfamily member and has been designated TNFSF13B. Produced by macrophages, dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, in resting CD4+ T cells, in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly, A/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. In contrast, BCMA- or TACI-deficient mice have no major defect in B-cell development. While the function of BCMA is not defined, TACI has been shown to control B-cell homeostasis and T-cell-independent immune responses.
Immunogen	Recombinant Human CD268 protein
Abbre	CD268
Swissprot	Q96RJ3
Host	Mouse
Reactivity	Human
Clonality	Monoclonal
Purification Method	>98%, Protein A/G purified
Isotype	Mouse IgG1, κ
Isotype Control	Purified Mouse IgG1, κ Isotype Control[MOPC-21], Functional Grade
Applications	FCM
Research Areas	Signal Transduction;CDs;NF-kB Signaling Pathway
Cellular Localization	Membrane
Tissue Specificity	Spleen and lymph node
Concentration	≥ 1 mg/mL
Conjugation	Unconjugated
Storage Buffer	Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
Storage	Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Expiration Date	12 months

Cat.No.	Product Name	Clone No.
AN003160P	Purified Anti-Human CD268 Antibody[11C1]	11C1
AN006550P	Purified Anti-Human CD268 Antibody[H353-6G10]	H353-6G10
AN007780P	Purified Anti-Human CD268 Antibody[H353-4A2]	H353-4A2