Purified Anti-Human CD276 Antibody[7-517] (AN012960P)
| Alternate Names | CD276 antigen, B7H, UNQ, PRO, B7-H, B7RP, B7 homolog, B7H34Ig-B7-H, PSEC, 4Ig-B7-H, CD276, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2, B7 homolog 3, B7H34Ig-B7-H3, CD276 antigen, CD276 molecule, Costimulatory molecule, PSEC0249, UNQ309, PRO352, B7RP-2, 4Ig-B7-H3, B7H3, B7-H3 |
| Clone | |
| Verified Samples | Verified Samples in FCM: PC-3 |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | B7-H3, assigned as CD276, is a type I transmembrane protein and shares 20-27% amino acid identity with other B7 family members. Human B7-H3 has a single extracellular variable-type immunoglobulin (IgV)-IgC domain, a signature intracellular domain, and an additional isoform, known as 4Ig-B7-H3, containing nearly exact tandem duplication of the IgV-IgC domain and most likely caused by exon duplication. B7-H3 mRNA is broadly expressed in normal tissues whereas its protein expression is relatively rare. The expression of B7-H3 is induced on T cells, natural killer (NK) cells, and antigen-presenting cells (APCs), including dendritic cells (DCs) and macrophages. It can be upregulated during the maturation from monocytes to DCs, or during the interaction between DCs and regulatory T cells. B7-H3 has been shown to be a co-stimulatory molecule that inhibits T-cell responses. B7-H3 has also been identified to bind TLT-2 involved in the intracellular signaling pathway. |
| Immunogen | Recombinant Human CD276 protein |
| Abbre | CD276 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1, κ |
| Isotype Control | Purified Mouse IgG1, κ Isotype Control[MOPC-21], Functional Grade |
| Applications |
FCM
|
| Research Areas | Tumor Biomarkers;Stem Cells;Cancer;Immunology;CDs;Hematopoietic Stem Cell Markers |
| Cellular Localization |
Membrane
|
| Concentration |
≥1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Cat.No. | Product Name | Clone No. |
|---|---|---|
| AN004110P | Purified Anti-Human CD276 Antibody[6A1] | 6A1 |
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