Purified Anti-Human CD366 Antibody[F38-2E2] (AN009710P)
![Purified Anti-Human CD366 Antibody[F38-2E2] - 1](http://file.elabscience.com/assets/images/loading.png)
| Verified Samples | Verified Samples in FCM: Daudi cells |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Isotype | Mouse IgG1, κ |
| Host | Mouse |
| Reactivity | Human |
| Applications | FCM |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human CD366 protein |
| Abbre | CD366 |
| Synonyms | KIM, T-cell immunoglobulin mucin receptor, TIM, HAVCR2, CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3, FLJ14428, Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, T cell immunoglobulin and mucin domain containing protein 3, hepatitis virus cellular receptor 2 |
| Swissprot | |
| Cellular Localization | Cell junction, Cell membrane, Membrane |
| Tissue Specificity | Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. |
| Concentration | ≥ 1 mg/mL |
| Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Purification Method | >98%, Protein A/G purified |
| Research Areas | Immunology |
| Clone No. | F38-2E2 |
| Conjugation | Unconjugated |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance. |
| Cat.No. | Product Name | Clone No. |
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