Purified Anti-Human IL-21 Antibody[3A3-N2] (E-AB-F1202A)
![Purified Anti-Human IL-21 Antibody[3A3-N2] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
| Alternate Names | CVID, Interleukin, IL21, CVID11, IL-21, Za11, Interleukin-21 |
| Clone No | |
| Leadtime | Inquire |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Human IL-21 gene |
| Dilution | FCM 2 μg/mL(1×105-5×105 cells) |
| Background | Interleukin-21 (IL-21) is the most recently described cytokine belonging to the common cytokine receptor gamma-chain family. Like other common gamma chain family members, IL-21 is a four alpha-helix bundle type I cytokine. It signals through a receptor complex consisting of IL-21 R and common gamma-chain/IL-2 R gamma. IL-21 is produced primarily by CD4+ T cells and natural killer T (NKT) cells and has a broad range of effects on a number of different cell types. IL-21 signaling in CD4+ T cells is required for both Th17 differentiation and the geneRation of T follicular helper (Tfh) cells, which support B cell differentiation and antibody production in germinal centers. IL-21 also directly regulates B cell prolifeRation and apoptosis in a context-dependent manner and can promote immunoglobulin production and isotype class switching. In addition, IL-21 signaling enhances the cytotoxicity of CD8+ T cells, natural killer cells, and NKT cells. |
| Immunogen | Recombinant Human IL-21 protein |
| Abbre | IL-21 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG1,κ |
| Applications |
FCM
|
| Cellular Localization |
Secreted
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
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Other Formats
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APC
Elab Fluor®700
PE
Unconjugated
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