Purified Anti-Mouse CD4 Antibody[RM4-5]

All	Size	Price	Qty
	100μg	$ 50.00
	25μg	$ 20.00
	100mg	$ 3800.00
	50mg	$ 2700.00
	25mg	$ 1800.00
	5mg	$ 540.00
	1mg	$ 148.00

Alternate Names	L3T, T-cell surface antigen T4/Leu, T-cell surface glycoprotein CD, L3T4, Ly-4, T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, Cd4, L3T4, CD4mut, p55
Clone No	RM4-5
Leadtime	Inquire
Verified Samples	Verified Samples in FCM: C57/BL6 Mouse splenocytes
Dilution	FCM 2 μg/mL(1×10⁵-5×10⁵ cells)
Background	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Immunogen	Recombinant Mouse CD4 protein
Abbre	CD4
Swissprot	P06332
Host	Rat
Reactivity	Mouse
Clonality	Monoclonal
Purification Method	>98%, Protein A/G purified
Isotype	Rat IgG2a,κ
Applications	FCM
Concentration	≥ 1 mg/mL
Conjugation	Unconjugated
Storage Buffer	Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
Storage	Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Expiration Date	12 months
Shipping	Ice bag

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Purified Anti-Mouse CD4 Antibody[RM4-5] (E-AB-F13530P)

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