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QuicKey Pro Human CD5L (CD5 Antigen-like) ELISA Kit (E-OSEL-H0080)

QuicKey Pro Human CD5L (CD5 Antigen-like) ELISA Kit - 1
  • QuicKey Pro Human CD5L (CD5 Antigen-like) ELISA Kit - 1
  • QuicKey Pro Human CD5L (CD5 Antigen-like) ELISA Kit - 2
  • QuicKey Pro Human CD5L (CD5 Antigen-like) ELISA Kit - 3
All Size Price Qty
96T $ 520.00
- +
48T $ 416.00
- +
24T $ 150.00
- +
96T*5 Inquire /
96T*10 Inquire /
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For research use only.

Product Summary

Get more sensitive and precise results with saving at least 1-2h comparing to traditional ELISA Kits. The new developed technology in house will help to accelerate your science research in a more efficient way.

Sensitivity 0.09 ng/mL
Detection Range 0.16-10 ng/mL
Sample Volume 50 μL
Total Assay Time 1 h 30 min
Reactivity Human
Specificity This kit recognizes Human CD5L in samples. No significant cross-reactivity or interference between Human CD5L and analogues was observed.
Recovery 80%-120%
Sample Type Serum, plasma and other biological fluids
Detection Method Colorimetric method, ELISA, Sandwich
Assay Type Sandwich-ELISA
Size 96T / 48T / 24T / 96T*5 / 96T*10
Storage 2-8℃
Expiration Date 6 months
Human CD5 antigen-like protein is a secretory protein that acts as a key regulator of lipid synthesis: it is mainly expressed by macrophages in lymphoid tissues and inflammatory tissues, regulating inflammatory response mechanisms such as infection or atherosclerosis. After entering mature adipocytes via CD36-mediated endocytosis, it binds to FASN in the cytoplasm, inhibiting fatty acid synthase activity, leading to lipolysis, i.e., the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-mediated intracellular lipid regulation has a direct impact on the transcriptional regulation of the nuclear receptor ROR-γ (RORC). By altering lipid content and limiting the synthesis of RORC cholesterol ligands, it regulates the expression of pro-inflammatory genes in Th17 cells. CD5L is mainly present in non-pathogenic Th17 cells, where it reduces the content of polyunsaturated fatty acid acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands for RORC, thereby limiting RORC activity and the expression of pro-inflammatory genes. By associating with IgM, it interferes with the binding of IgM to Fc alpha/mu receptors, promoting the development of long-lived plasma cells. In addition, it acts as an inhibitor of macrophage apoptosis: in atherosclerotic conditions, it promotes the survival of macrophages from apoptotic effects caused by oxidized lipids. It can also play a role in the early microbial infection response against various pathogens by acting as a pattern recognition receptor and promoting autophagy.
Gene Alias CD5L
Gene ID 922
Uniport ID O43866
Protein Alias CD5L
Research Area 细胞生物学
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